| Project/Area Number |
26861635
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Osaka University |
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Principal Investigator |
TAKEDA KAHORU 大阪大学, 歯学部附属病院, 医員 (10711096)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ハイドロゲル / FGF-2 / 組織再生 / レジン系材料 |
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| Outline of Final Research Achievements |
In this study, the effects of novel non-biodegradable FGF-2-releasing polyHEMA-based hydrogel particles to promote tissue regeneration were evaluated in vitro and in vivo. Based on the results of in vitro tests, it was found that optimum FGF-2-releasing particles were obtained by loading FGF-2 using 500 μg/mL FGF-2 solution with freeze-drying process. Then, FGF-2 releasing hydrogel particles were embedded in 4-META/MMA-based adhesive resin and implanted to the cranial defect prepared in SD rats. Evaluation with micro CT after 4 weeks revealed that new bone formation around the implanted specimen, suggesting the possible usefulness of the experimental particles to induce bone regeneration.
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