Comprehensive analysis of bacterial flora around dental implants by Next Generation Sequencer and development of antibacterial therapy.

Research Project

Project/Area Number	26861637
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Prosthodontics/ Dental materials science and
Research Institution	Okayama University
Principal Investigator	Ono Aya 岡山大学, 大学病院, 助教 (20584626)
Research Collaborator	窪木拓男 (00225195) 大野充昭 (60613156)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	口腔インプラント / インプラント周囲炎 / 細菌叢 / 次世代シークエンサー / メタゲノム解析 / 歯学 / 臨床疫学
Outline of Final Research Achievements	It is still unclear the constitution of bacteria in peri-implantitis. We analyzed the bacterial flora of the exudate around dental implant body suffered from peri-implantitis by NGS. The experimental results were revealed that there are differences between individuals in the bacterial flora, and the peri-implantitis and the periodontal disease were similar bacterial flora and the healthy dental implants and the healthy tooth were also similar in the bacterial flora.