Reaction of brain redox on oral rehabilitation in cerebral infarction animal model under percutaneous endoscopic gastrostomy placement

• Project/Area Number: 26861649
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: KAWANISHI Katsuya 北海道医療大学, 歯学部, 講師 (10438377)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脳梗塞 / 抗酸化能 / 舌運動 / マイクロダイアリシス / 尿酸 / 咀嚼 / 海馬 / 経管栄養摂取 / 咬合

Outline of Final Research Achievements

The purpose of this study was to investigate whether the oral rehabilitation contributes the functional recovery from stroke-induced compromised antioxidant ability in cerebral ischemic rat model. The measurement of the antioxidant ability in the CA1 region of the hippocampus was performed by using the HPLC-ECD.
An antioxidant ability was increased at the stimuli by not tubal feeding, but oral nutrition intake. These results suggested that the nutritional support through a tube inserted into the stomach without oral intake may have a negative effect on recovery from cerebral infarction.

Research Products

• [Journal Article] The evolution of research on occlusion and brain function (2017)
  • Author(s): T Hara, K Kawanishi, A Ohno, S Iida.
  • Journal Title: Journal of Prosthodontic Research Volume: 61 Issue: 1 Pages: 6-8
  • DOI: 10.1016/j.jpor.2016.06.001
  • NAID: 130005465173
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The relationship between occlusal-masticatory function and brain function in cerebral infarction model rats (2016)
  • Author(s): 川西克弥，佐々木みづほ，豊下祥史，會田英紀，越野 寿
  • Journal Title: Annals of Japan Prosthodontic Society Volume: 8 Issue: 4 Pages: 358-363
  • DOI: 10.2186/ajps.8.358
  • NAID: 130005279571
  • ISSN: 1883-4426, 1883-6860
  • Peer Reviewed / Open Access
• [Journal Article] 脳梗塞モデルラットにおける高次脳機能障害の回復に対する咀嚼の有効性 (2014)
  • Author(s): 佐々木みづほ、豊下祥史、川西克弥、會田英紀、越野 寿
  • Journal Title: 日本咀嚼学会雑誌 Volume: 24 Pages: 50-58
  • Peer Reviewed / Open Access
• [Presentation] 咬合支持の有無と脳機能研究の展開 (2015)
  • Author(s): 原 哲也、川西克弥、大野晃教、飯田祥与
  • Organizer: 公益社団法人日本補綴歯科学会第124回学術大会
  • Place of Presentation: 埼玉県（さいたま市）
  • Year and Date: 2015-05-30
• [Presentation] 咬合支持の有無と脳機能研究の展開 (2015)
  • Author(s): 川西克弥
  • Organizer: 日本補綴歯科学会第124回学術大会
  • Place of Presentation: 大宮ソニックシティ（埼玉県・さいたま市）
  • Year and Date: 2015-05-30
• [Presentation] 飼料摂取経路の違いが脳梗塞モデルラットの抗酸化能低下からの回復に及ぼす影響 (2014)
  • Author(s): 川西克弥、佐々木みづほ、菅 悠希、豊下祥史、會田英紀、越野 寿
  • Organizer: 日本咀嚼学会第25回総会・学術大会
  • Place of Presentation: 静岡県立大学谷田キャンパス（静岡県・静岡市）
  • Year and Date: 2014-09-20 – 2014-09-21