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Fabrication of nano-modified implant material for diabetes patients

Research Project

Project/Area Number 26861664
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionOsaka Dental University

Principal Investigator

KOMASA Satoshi  大阪歯科大学, 歯学部, 助教 (70632066)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsナノ材料 / インプラント / 糖尿病 / TNS / ナノ構造
Outline of Final Research Achievements

Since the morbidity risk of peri-implant inflammation is increased by the prolonged wound healing period in diabetic patients suffering from a lifestyle-related diseases, early osseointegration acquisition is expected. Therefore, nano-structure precipitated pure titanium, which in this study which was added to the heating process, which has been reported to induce bone formation in the early stage was examined the impact of the hard tissue differentiation-inducing ability of rats under the diabetes environment. It was higher as compared with untreated pure titanium in the nanostructures pure titanium with normal and high glucose immersion group was evaluated for various differentiation markers. The above results suggested one end of possibility of nanostructures regardless of changes in glucose concentration to induce a reliable primary stability.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (10 results)

  • [Journal Article] Bioactivity of Titanium Surface Nanostructures Following Chemical Processing and Heat Treatment2015

    • Author(s)
      Komasa S, Su YM, Taguchi Y, Yamawaki I, Tsutsumi Y, Kusumoto T, Nishizaki H, Miyake T, Umeda M, Tanaka M, Okazaki J
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 24(3) Pages: 257-266

    • NAID

      130005088085

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a nanosheet surface structure of titanium on initial attachment of cells2015

    • Author(s)
      Komasa S, Taguchi Y, Nakazawa Y, Kusnoki T, Tashiro Y, Kusumoto T, Nishizaki H, Komasa Y, Okazaki J
    • Journal Title

      日本口腔リハビリテーション学会雑誌

      Volume: 28(1) Pages: 1-10

    • NAID

      40020724533

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Porphyromonas gingivalis lipopolysaccharide on bone marrow mesenchymal stem cell osteogenesis on a titanium nanosurface2015

    • Author(s)
      H. Xing, Y. Taguchi, S. Komasa, I. Yamawaki, T. Sekino, M. Umeda, and J. Okazaki
    • Journal Title

      Journal of Periodontology

      Volume: 86 Issue: 3 Pages: 448-455

    • DOI

      10.1902/jop.2014.140386

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Nanosheet Surface Structure of Titanium Alloys on Cell Differenciation2014

    • Author(s)
      Komasa S, Kusumoto T, Taguchi Y, Nishizaki H, Sekino T, Umeda M, Okazaki J
    • Journal Title

      Journal of Nanomaterials

      Volume: 2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Osteogenesis related gene expression on titanium surfaces with nano-network structures formed by treatment with alkali solutions2014

    • Author(s)
      Komasa S, Xing H, Taguchi Y, Kayama T, Fujio M, Miyake A, Shimamura S, Kusumoto T, Nishizaki H, Okazaki J
    • Journal Title

      Journal of Osaka Dental University

      Volume: 48(2) Pages: 133-139

    • NAID

      110009865347

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ナノ構造析出純チタン金属に加熱処理が与える影響について2016

    • Author(s)
      藤尾 美穂, 小正  聡, 西崎 真理子, 西崎 宏, 岡崎 定司
    • Organizer
      バイオインテグレーション学会第6回学術大会・総会
    • Place of Presentation
      大阪歯科大学100周年記念会館(大阪府・大阪市)
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] アルカリ加熱処理を施したナノ構造制御Ti6Al4V合金ー特性評価と細胞接着ー2015

    • Author(s)
      蘇 英敏, 小正  聡, 関野 徹, 西崎 宏, 岡崎 定司
    • Organizer
      公益社団法人日本口腔インプラント学会 第35回近畿・北陸支部学術大会
    • Place of Presentation
      北國新聞赤羽ホール(石川県・金沢市)
    • Year and Date
      2015-12-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] チタン合金への濃アルカリ処理が硬組織形成誘導に与える影響について2015

    • Author(s)
      小正  聡, 田口 洋一郎, 西崎 真理子, 楠本 哲次, 西崎 宏, 岡崎 定司
    • Organizer
      第29回日本口腔リハビリテーション学会学術大会
    • Place of Presentation
      徳島大学長井記念ホール(徳島県・徳島市)
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] グルコース濃度の変化がTNS析出純チタン金属表面に及ぼす影響について2015

    • Author(s)
      小正  聡, 田口 洋一郎, 蘇 英敏, 藤尾 美穂, 西崎 真理子, 内藤 大介, 楠本 哲次, 西崎 宏, 岡崎 定司
    • Organizer
      平成27年度日本補綴歯科学会関西支部学術大会
    • Place of Presentation
      兵庫医療大学(兵庫県・神戸市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] ナノ構造制御チタン金属表面における硬組織分化誘導に及ぼすグルコース濃度の影響2015

    • Author(s)
      山脇 勲, 田口 洋一郎, 小正  聡, 小石 玲子, 奥田 麻貴子, 田中 昭男, 梅田 誠
    • Organizer
      平成27年度第58回春季日本歯周病学会学術大会
    • Place of Presentation
      幕張メッセ(千葉県・千葉市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 化学合成法によるチタン合金表面上へのナノ構造の析出と生体適合性評価2015

    • Author(s)
      小正 聡, 西崎 宏, 岡崎定司
    • Organizer
      公益社団法人日本セラミックス協会 2015年年会
    • Place of Presentation
      岡山大学(岡山県,岡山市)
    • Year and Date
      2015-03-18 – 2015-03-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of Titanium Surfaces With Various Alkali Concentration on Osteogenic Differentiation2015

    • Author(s)
      Komasa S, Taguchi Y, Xing H, Kusumoto T, Fujio M, Terada C, Nishizaki H, Okazaki J
    • Organizer
      93rd General session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] チタン合金表面上に析出させたTNS構造が細胞の初期接着に与える影響について2014

    • Author(s)
      小正 聡, 田口洋一郎, 楠本哲次, 西崎 宏, 岡崎定司
    • Organizer
      第44回 日本口腔インプラント学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都,千代田区)
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Research-status Report
  • [Presentation] チタン合金表面に析出されたナノ構造への加熱処理がラットの骨髄細胞の硬組織分化誘導脳に与える影響について2014

    • Author(s)
      小正 聡, 蘇 英敏, 田口洋一郎, 楠本哲次, 関野 徹, 西崎 宏, 田中昌博, 岡崎定司
    • Organizer
      平成26年度公益社団法人 日本補綴歯科学会 中国・四国、関西支部合同学術大会
    • Place of Presentation
      倉敷市芸文館(岡山県,倉敷市)
    • Year and Date
      2014-09-06 – 2014-09-07
    • Related Report
      2014 Research-status Report
  • [Presentation] QCMセンサを利用したジルコニアおよび純チタン金属表面へのPRP吸着量の比較.2014

    • Author(s)
      小正 聡, 三宅晃子, 橋本典也, 中野蓉子, 田口洋一郎, 楠本哲次, 西崎 宏, 岡崎定司
    • Organizer
      公益社団法人日本歯科補綴歯科学会第123回学術大会
    • Place of Presentation
      仙台国際センター(宮城県,仙台市)
    • Year and Date
      2014-05-24 – 2014-05-25
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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