Elucidation of immunoreaction mechanism in allogeneic periodontal ligament cell transplantation

Research Project

Project/Area Number	26861670
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Dental engineering/Regenerative dentistry
Research Institution	Tokyo Medical and Dental University
Principal Investigator	Tsumanuma Yuka 東京医科歯科大学, 歯学部附属病院, 医員 (70726265)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	歯根膜幹細胞 / 免疫調節機構
Outline of Final Research Achievements	In this study we found that the allogeneic periodontal ligament-derived multipotent MSCs (PDL-MSCs) regenerated periodontal tissue without an intense inflammatory reaction in the dog model. Serum levels of inflammatory markers from peripheral blood sera showed little difference between the autologous and allogeneic groups. PDL-MSCs may regulate the immunoreaction. However the mechanism of the iimmuno- modulatory properties of PDL-MSCs is not well understood. Therefore, second purpose of this study was to elucidate the interaction between PDL-MSCs and the immune cells.The result showed that the human PDL-MSCs might regulate the immune reaction in the co-culture experiment.

Report

(3 results)