Elucidation of immunoreaction mechanism in allogeneic periodontal ligament cell transplantation
| Project/Area Number |
26861670
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Tsumanuma Yuka 東京医科歯科大学, 歯学部附属病院, 医員 (70726265)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯根膜幹細胞 / 免疫調節機構 |
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| Outline of Final Research Achievements |
In this study we found that the allogeneic periodontal ligament-derived multipotent MSCs (PDL-MSCs) regenerated periodontal tissue without an intense inflammatory reaction in the dog model. Serum levels of inflammatory markers from peripheral blood sera showed little difference between the autologous and allogeneic groups. PDL-MSCs may regulate the immunoreaction. However the mechanism of the iimmuno- modulatory properties of PDL-MSCs is not well understood. Therefore, second purpose of this study was to elucidate the interaction between PDL-MSCs and the immune cells.The result showed that the human PDL-MSCs might regulate the immune reaction in the co-culture experiment.
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Report
(3 results)
Research Products
(2 results)
