Direct induction of osteoblast from human Gingival fibroblast cells

Research Project

Project/Area Number	26861678
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Dental engineering/Regenerative dentistry
Research Institution	Nagasaki University
Principal Investigator	SHIRAISHI Takeshi 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (00613580)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	ダイレクトリプログラミング / ADSCｓ / エレクトロポレーション
Outline of Final Research Achievements	A loss of an alveolus bone and a jawbone will be the cause which makes patient's QOL fall. The method of direct reprogramming　is reported to chondrocytic from fiber blastic in recent years. Therefore we studied the procedures to guide osteoblasts using the direct reprogramming method from human gingival fibroblast cells in this study.The genetic manifestation of RNUX-2 and BMP-4 was confirmed by genetic introduction by electroporation way.

Report

(3 results)