Regulatory mechanism of bone differentiation by Wnt inhibitory factor
| Project/Area Number |
26861686
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
onodera shoko 東京歯科大学, 歯学部, 助教 (90637662)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨芽細胞分化 / Wnt経路 / 歯根膜細胞 / WNT経路 / iPS細胞 / 再生医療 |
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| Outline of Final Research Achievements |
In this study,we focused on the relationship between WNT signaling pathway, especially WNT inhibitors, and osteoblasts to elucidate the mechanism of BMP related osteoblast differentiation.Osteoblast differentiation using human periodontal ligament fibroblasts hPDLF was suggested that one of the inhibitor of WNT pathway sclerostin worked strongly in bone formation. Sclerostin is expected as a therapeutic agent for bone formation from being a target of osteoporosis.
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Report
(3 results)
Research Products
(16 results)
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[Presentation] Gorlin症候群患者由来iPS細胞を用いた骨芽細胞分化応答2016
Author(s)
小野寺 晶子,大庭 伸介,長谷川 大悟,斎藤 暁子,篠 宏美,渡邊 章,大高 真奈美,西村健,中西 真人,片倉 朗,鄭 雄一,柴原 孝彦,東 俊文
Organizer
大阪国際会議場（大阪）
Place of Presentation
大阪国際会議場（大阪）
Year and Date
2016-03-17
Related Report
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[Presentation] Characterization of iPS cells derived from basal cell nevus syndrome primary oral tissue fibroblast.2015
Author(s)
小野寺 晶子,大庭 伸介,長谷川 大悟,斎藤 暁子,篠 宏美,渡邊 章,大高 真奈美,西村健,中西 真人,片倉 朗,鄭 雄一,柴原 孝彦,東 俊文
Organizer
BMB2015（第 38回日本分子生物学会年会、第 88回日本生化学会大会）
Place of Presentation
神戸ポートアイランド（兵庫）
Year and Date
2015-12-01
Related Report
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