Periodontal regeneration induced by using a complex of implant and cultured periodontal ligament cell sheet
Project/Area Number |
26861687
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Tokyo Women's Medical University |
Principal Investigator |
Washio Kaoru 東京女子医科大学, 医学部, 特任講師 (50514486)
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Research Collaborator |
YANO Kousei
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 歯根膜細胞シート / インプラント / 歯周組織再生 / 歯根膜 / 細胞シート / 歯科インプラント / チタン |
Outline of Final Research Achievements |
Osseo-integrated implants have been used world-widely and contributed to keep good function and aesthetic dentistry. Recently, peri-implantitis lesion is known as a common clinical case after 5 to 10 years in use without treatment. Host-defense mechanism around implant is limited because of lack of blood circulation around implant, which is caused by the lack of periodontal ligament (PDL). The aim of this study is making a complex of implant and PDL cells. Firstly, we found the PDL cell sheets was attached to the titanium with treated surface. Next, the complex of titanium implant and PDL cell sheet was inserted into a drilled hole on canine mandible and covered with gingival flap for about 3 months. The histological results showed that periodontal ligament-like-structure was induced on the treated surface of titanium implant. The presence of a PDL around the implant allows for a more dynamic role beyond the functionally osseo-integrated implant.
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Report
(4 results)
Research Products
(6 results)
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[Presentation] 歯根膜細胞シート付着型インプラントの開発2016
Author(s)
鷲尾薫, 堤 祐介, 妻沼 有香, Supreda Suphanantachat, 矢野 孝星, 市野瀬 志津子, 大和雅之, 岡野光夫, 塙隆夫, 石川烈
Organizer
第25回インテリジェント材料・システムシンポジウム
Place of Presentation
東京女子医科大学 先端生命医科学研究所
Year and Date
2016-01-08
Related Report
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[Presentation] New Periodontal-like Tissue Formation on the Modified Titanium Surface2015
Author(s)
Washio Kaoru, Tsutsumi Yusuke, Tsumanuma Yuka, Suphanantachat Supreda, Yano Kosei, Ichinose Shizuko, Yamato Masayuki, Okano Teruo, Hanawa Takao, Ishikawa Isao
Organizer
11th Asian pacific society of Periodontology meeting 2015
Place of Presentation
South Bali, Indonesia
Year and Date
2015-10-08
Related Report
Int'l Joint Research
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