| Project/Area Number |
26861692
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯槽骨再生 / 合成コラーゲン / 骨再生 / 血小板凝集能 / αリン酸三カルシウム / 人工コラーゲン |
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| Outline of Final Research Achievements |
We evaluated the bone reproduction ability of combining the mesenchymal stem cells (MSCs) derived from the pig marrow collected, separated, and adjusted in advance with polypeptides consisting of a Pro-Hyp-Gly sequence (poly(PHG) ) sponge. For the transplantation experiment, the cell group using poly(PHG) sponge as a scaffold, the group of only poly(PHG) sponge, and the group of only a bone defect as a control group, were produced. The percentage of new bone in the cell group was significantly greater than that in the control group at weeks 12 and 18 in the microradiography. At week 18, the poly(PHG) were almost degraded and remodeling of the mature compact bone was observed in the cell group. Bone formation materials that combine poly(PHG) sponge as a scaffold with MSCs have good osteogenic ability, and should be studies for clinical application.
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