Osteogenesis by gradually expanding the interface between bone surface and periosteum

• Project/Area Number: 26861702
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tsurumi University
• Principal Investigator: SATO KOICHIRO 鶴見大学, 歯学部, 学部助手 (20728125)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 骨再生 / 骨膜 / 組織延長術 / 再生医療 / 骨・骨膜間空隙拡大 / 組織延長

Outline of Final Research Achievements

We are investigating to regenerate bone by osteogenesis by gradually expanding the interface between bone surface and periosteum.In this study we deveroped the new bone argmentation to obtain alternative strategies for periosteal distraction to induce effective bone formation that will lead to a reduction of the treatment period and to obtain functional bone capable of withstanding occlusal force.The experimental group of fibrin geland MSC showed significantly increased volume in newly formed bone tissues compared with the control group at critical size defect.However micro-CT and histological analysis demonstrated that the effects of periosteal distraction were not enhanced by administration of bone marrow stem
cells and fibrin gel.

Research Products

• [Journal Article] A Strategy against the Osteonecrosis of the Jaw Associated with Nitrogen-Containing Bisphosphonates (N-BPs): Attempts to Replace N-BPs with the Non-N-BP Etidronate. (2016)
  • Author(s): Oizumi T, Yamaguchi K, Sato K, Takahashi M, Yoshimura G, Otsuru H, Tsuchiya M, Hagiwara Y, Itoi E, Sugawara S, Takahashi T, Endo Y
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Pages: 1549-1554
  • NAID: 130005262320
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Possible Immune Regulation of Natural Killer T Cells in a Murine Model of Metal Ion-Induced Allergic Contact Dermatitis. (2016)
  • Author(s): Kumagai K, Horikawa T, Shigematsu H, Matsubara R, Kitaura K, Eguchi T, Kobayashi H, Nakasone Y, Sato K, Yamada H, Suzuki S, Hamada Y, Suzuki R.
  • Journal Title: International journal of molecular sciences Volume: 12 Issue: 1 Pages: 87-87
  • DOI: 10.3390/ijms17010087
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 顎変形症術後のヒロサームによる冷罨法の抗炎症効果とサイトカインバランスの改善 (2016)
  • Author(s): 佐藤光一郎、中岡一敏、荒井俊明、熊谷賢一、長谷部充彦、馬杉亮彦、園山智生、濱田良樹
  • Organizer: 第61回日本口腔外科学会総会
  • Place of Presentation: 幕張メッセ（千葉県、千葉市）
  • Year and Date: 2016-11-25
• [Remarks] 鶴見大学歯学部口腔顎顔面外科学講座 研究内容・業績
  • URL: http://ccs.tsurumi-u.ac.jp/oms/research.html
• [Remarks] 鶴見大学 歯学部 口腔顎顔面外科学講座 研究内容・業績
  • URL: http://ccs.tsurumi-u.ac.jp/oms/research.html