| Project/Area Number |
26861705
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Michikawa Chieko 東京医科歯科大学, 歯学部附属病院, 医員 (00622648)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 被膜外浸潤 / 分類 / リンパ節 / 口腔癌 / 扁平上皮癌 / 頸部リンパ節転移 / リンパ節転移 |
|---|
| Outline of Final Research Achievements |
Extracapsular spread (ECS) of cervical lymph node metastasis in oral squamous cell carcinoma (OSCC) is independently recognized as the only marker of World Standard for planning post-operative chemoradiotherapy. I investigated the status of metastatic lymph nodes pathologically and morphologically in detail, and found that the patients with small nodes but ECS positive showed significantly worse outcome compared to those with ECS positive larger nodes. Moreover, I performed next generation sequencer using genomic DNA from primary OSCC and metastasis with ECS to seek genetic alterations associated with ECS.
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