Oral cancer intraoperative detection by fluorescent probe.
| Project/Area Number |
26861710
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Shinshu University |
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Principal Investigator |
SHIMANE Tetsu 信州大学, 医学部附属病院, 特任研究員 (80714469)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | GGT / 口腔癌 / 扁平上皮癌 / アミノ酸代謝 / 術中診断 / γ-Glu / グルタミル基 / 蛍光 / 迅速診断 / in vivo / 口腔がん / SCC / ｇGlu-HMRG / 口腔扁平上皮癌 |
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| Outline of Final Research Achievements |
The ability of the unaided human eye to detect accurate borders between cancer and normal tissue during surgery is limited. The aim of this study was to evaluate the performance of g-Glu-HMRG in distinguishing oral squamous cell carcinoma (OSCC) from normal tissue. After removing OSCC, g-Glu-HMRG was sprayed on the surface of fresh sliced section of OSCCs. Fluorescent images were obtained by in vivo imager. Fluorescence was firstly confirmed at invasive fronts of OSCC 1 to 3 minutes after the spraying. 25 minutes after the spraying, we could distinguish whole OSCC invasive fronts from normal tissue. In conclusion, the results of this study demonstrated that g-Glu-HMRG could rapidly detect OSCC invasive front. Instant activation of the probe makes it feasible for incorporation into surgical intraoperative resection procedures.
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Report
(3 results)
Research Products
(7 results)
