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ASC change the chemotherapy -the regulation of ASC expression-

Research Project

Project/Area Number 26861711
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionShinshu University

Principal Investigator

ITOH Ryuichi  信州大学, 医学部附属病院, 特任研究員 (70646661)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsASC / 口腔癌 / 扁平上皮癌 / apoptosis / cell differentiation / TUNEL / メチル化 / DNA / 分化 / 予後バイオマーカー / ASC発現 / 口腔扁平上皮癌細胞 / DNAのメチル化
Outline of Final Research Achievements

To assess apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) expression in oral squamous cell carcinoma (OSCC) and analyze its clinical and pathological significance.ASC expression was studied using immunohistochemistry in 119 OSCCs patients. The relationships between ASC expression and clinical and pathological parameters were statistically analyzed. In addition, the relationships between ASC expression and cell differentiation marker expression and apoptosis cells were investigated.ASC expression showed significant correlations with parameters including clinical tumor stage, mode of invasion, and histological differentiation, and had a significant impact on survival of OSCC. ASC expression was significantly correlated with the apoptosis cells.
Lower ASC expression correlates with clinical and pathological malignancy and, consequently, poor prognosis of OSCC. ASC has a close association with cell differentiation and apoptosis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Oral cancer intraoperative detection by topically spraying a γ-glutamyl transpeptidase-activated fluorescent probe.2016

    • Author(s)
      Shimane T, Aizawa H, Koike T, Kamiya M, Urano Y, Kurita H.
    • Journal Title

      Oral oncology

      Volume: 54 Pages: e16-e18

    • DOI

      10.1016/j.oraloncology.2015.12.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells.2016

    • Author(s)
      Chen W, Yi JK, Shimane T, Mehrazarin S, Lin YL, Shin KH, Kim RH, Park NH, Kang MK.
    • Journal Title

      Carcinogenesis

      Volume: 1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed

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Published: 2014-04-04   Modified: 2017-05-10  

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