Pathogenesis in the maxillofacial area by using a disease-specific iPS cells
Project/Area Number |
26861715
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Kyoto University |
Principal Investigator |
Koyama Noriaki 京都大学, 医学(系)研究科(研究院), 研究員 (30599931)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | iPS細胞 / 骨軟骨再生 / 軟骨異形成症 / 線維性異形成症 / 軟骨骨再生 / 軟骨無形成症 |
Outline of Final Research Achievements |
There is a lot of disease that happen from abnormal membrane ossification and endochondral ossification occur to jaw deformation in the maxillofacial area. To establish a treatment method using the Pathogenesis and various factors by using a bone lineage disease-specific iPS cells.We collected FD lesion from FD patients and we cultured human FD cells. Although we could get wild-type iPS cells, we couldn't establish human iPS cells from the FD cells mutation yet.
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Report
(3 results)
Research Products
(6 results)
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[Presentation] CNP/GC-B系は局所因子として内軟骨骨化を促進する2014
Author(s)
中尾一祐, 八十田明宏, 大澤賢次, 山中茂樹, 小山典昭, 近藤絵里, 藤井寿人, 三浦晶子, 稲垣暢也, 別所和久, 中尾一和
Organizer
第32回日本骨代謝学会学術集会
Place of Presentation
大阪市
Year and Date
2014-07-24 – 2014-07-26
Related Report
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[Presentation] ヒトiPS細胞からの軟骨細胞分化誘導におけるCNPの作用に関する検討2014
Author(s)
三浦晶子, 小山典昭, 中尾一祐, 上田依利子, 山下唯, 近藤絵里, 藤井寿人, 金本巨哲, 曽根正勝, 八十田明宏, 荒井宏司, 別所和久, 稲垣暢也, 中尾一和
Organizer
第87回日本内分泌学会学術総会
Place of Presentation
福岡市
Year and Date
2014-04-24 – 2014-04-26
Related Report
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[Presentation] 内軟骨骨化の顎顔面形態に対する影響~軟骨細胞特異的CNP遺伝子改変マウスを用いた研究~2014
Author(s)
山中茂樹, 中尾一祐, 八十田明宏, 小山典昭, 磯部悠, 池野正幸, 藤井寿人, 近藤絵里, 三浦晶子, 中尾一和, 別所和久
Organizer
第87回日本内分泌学会学術総会
Place of Presentation
福岡市
Year and Date
2014-04-24 – 2014-04-26
Related Report