| Project/Area Number |
26861718
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
HARADA TAKESHI 大阪大学, 歯学研究科(研究院), 研究員 (00403030)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 嚥下運動 / WHBP標本 / サブスタンスP / セトロニン / ドーパミン / セロトニン / 嚥下中枢 |
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| Outline of Final Research Achievements |
It was revealed the involvement of substance P and serotonin in swallowing movement by using working heart brainstem preparation (WHBP). In addition, as an effective method to evaluate the central nervous mechanism in swallowing movement, it was establish micro injection method into the medulla oblongata nucleus of the solitary tract in WHBP.
Substance P is promoted the swallowing movement, it was shown that the mechanism through the neurokinin-1 receptor in nucleus of the solitary tract. Furthermore, serotonin is inhibited the swallowing movement, it was suggested that the mechanism through serotonin receptor in nucleus of the solitary tract.
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