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Practical application of oral cancer screening by mass spectrometry

Research Project

Project/Area Number 26861719
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionTokyo Medical University (2016)
Kobe University (2014-2015)

Principal Investigator

KIMOTO AKIRA  東京医科大学, 医学部, 助教 (30597167)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords口腔がん / メタボローム解析 / スクリーニング / バイオマーカー
Outline of Final Research Achievements

Oral cancer is one of the most commom cancer. There are several types of oral cancers, but around 90% are squamous cell carcinoma. It is usually painless for a considerable length of time and can spread to the lymph nodes. It is important to detect oral cancer at an early stage. There are no serum or plasma biomarkers that are highly-sensitive and able to detect the early stage oral cancer. SCC-antigen, typical tumor marker of oral cancer, is low sensitivity and can’t detect early stage cancer. In this study, I subjected oral cancer patients' serum samples to gas chromatography(GC/MS)-based metabolomic analysis. Their preoperative serum metabolite levels were compared with those of healthy volunteers. In addition, pre- and postoperative serum metabolite levels were also compared. As a result of the analysis, seven biomarker candidates were detected. GC/MS-based metabolomic analysis is a promising method for detecting early-stage oral cancer.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] 担がんマウスモデルの血漿メタボローム解析による口腔がん特異的バイオマーカーの探索2015

    • Author(s)
      榎本由依・木本明・鰐渕聡・鈴木泰明・古森孝英
    • Organizer
      第60回公益社団法人日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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