Elucidation on the molecular mechanisms of the carcinogenesis and malignant transformation of oral cancer via DeltaNp63-mediated epithelial-mesenchymal transition

• Project/Area Number: 26861729
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: Matsubara Ryota 九州大学, 歯学研究院, 助教 (60615798)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ΔNp63 / 口腔扁平上皮癌 / 上皮-間葉転換（EMT） / KLK6 / miR-205 / 上皮－間葉転換（EMT） / 浸潤・転移

Outline of Final Research Achievements

The purpose of this study is elucidation on the molecular mechanisms of the carcinogenesis, invasion, and metastasis of oral squamous cell carcinoma (OSCC) via DeltaNp63-mediated epithelial-mesenchymal transition (EMT).
As the results, it is suggested that downregulation of DeltaNp63 induced EMT in OSCC. Furthermore, DeltaNp63 regulates KLK6 and miR-205 regarded as EMT-related molecules, and therefore DeltaNp63 possibly involved in acquirement of the invasion, metastasis of OSCC.

Research Products

• [Journal Article] 8.Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte-colony-stimulating factor: a case report and literature review (2016)
  • Author(s): Naoki Kaneko, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Taiki Sakamoto, Yuma Hashiguchi, Masakazu Iida, Seiji Nakamura
  • Journal Title: World Journal of Surgical Oncology Volume: 14 Pages: 161-161
  • Peer Reviewed / Open Access
• [Journal Article] Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone (2016)
  • Author(s): Shohei Yoshimoto, Hiromitsu Morita, Ryota Matsubara, Takeshi Mitsuyasu, Yuko Imai, Shunichi Kajioka, Masahiro Yoneda, Yushi Ito, Takao Hirofuji, Seiji Nakamura, Masato Hirata.
  • Journal Title: International Journal of Oncology Volume: 48 Pages: 1258-1270
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation (2015)
  • Author(s): Yasuyuki Maruse, Shintaro Kawano, Tamotsu Kiyoshima, Yuichi Goto, Ryota Matsubara R, Toru Chikui, Daigo Yoshiga, Seiji Nakamura
  • Journal Title: Head & Neck Volume: 37
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma (2015)
  • Author(s): Teppei Jinno T, Shintaro Kawano, Yasuyuki Maruse, Ryota Matsubara, Yuichi Goto, Taiki Sakamoto, Yuma Hashiguchi, Naoki Kaneko, Hideaki Tanaka, Ryoji Kitamura, Takeshi Toyoshima, Akiko Jinno, Masafumi Moriyama, Kazunari Oobu, Tamotsu Kiyoshima, Seiji Nakamura
  • Journal Title: Oncology Reports Volume: 33 Pages: 2161-2168
  • Peer Reviewed / Open Access
• [Journal Article] Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma (2014)
  • Author(s): Hideaki Tanaka, Takeshi Toyoshima, Kenzo Sonoda, Ryoji Kitamura, Masaaki Sasaguri, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Seiji Nakamura
  • Journal Title: Journal of Translational Medicine Volume: 12 Pages: 112-112
  • Peer Reviewed / Open Access
• [Journal Article] 6.Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype (2014)
  • Author(s): Yuichi Goto, Shintaro Kawano, Ryota Matsubara, Takahiro Kiyosue, Mitsuhiro Hirano, Teppei Jinnno, Yasuyuki Maruse, Takeshi Toyoshima, Ryoji Kitamura Hideaki Tanaka, Kazunari Oobu, Seiji Nakamura
  • Journal Title: Clinical and Experimental Metastasis Volume: 31 Pages: 293-306
  • Peer Reviewed / Open Access
• [Presentation] 蝶形骨に転移をきたした下顎骨中心性扁平上皮癌への対応 (2017)
  • Author(s): 松原良太
  • Organizer: 日本口腔腫瘍学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2017-01-26
• [Presentation] Clinical evaluation of oral squamous cell carcinoma patients with the synchronous second cancer detected by upper gastrointestinal fiberscopy (2016)
  • Author(s): Ryota Matsubara, Shintaro Kawano, Teppei Jinno, Yasuyuki Maruse, Naoki Kaneko, Taiki Sakamoto, Yuma Hashiguchi, Kazunari Oobu, and Seiji Nakamura
  • Organizer: The 28th Conference of the Taiwan Association of Oral and Maxillofacial Surgeons (TAOMS)
  • Place of Presentation: 台湾、台中市
  • Year and Date: 2016-03-05
  • Int'l Joint Research