Clinical application for biomarker RCAS1 in oral squamous cell carcinoma

• Project/Area Number: 26861730
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: Toyoshima Takeshi 九州大学, 歯学研究院, 共同研究員 (20546569)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: RCAS1 / 口腔扁平上皮癌 / 膜型 / 分泌型 / アポトーシス / 膜型RCAS1 / 分泌型RCAS1 / バイオマーカー

Outline of Final Research Achievements

Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) could induce apoptosis of immune cells for host with cancer, and lead to the growth. As RCAS1 has been expressed on several types of oral squamous (OSCC) cells, this antigen could play a role of biomarker for patients with OSCC.