Involvement of helper T cells in the pathogenesis of HTLV-1-related Sjogren's syndrome

• Project/Area Number: 26861733
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: TANAKA AKIHIKO 九州大学, 大学病院, その他 (70615799)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: シェーグレン症候群 / HTLV-1 / Th / サイトカイン / ケモカイン

Outline of Final Research Achievements

Sjogren's syndrome (SS) is a chronic inflammatory disease mainly composed of the lymphocyte permeation of the exocrine gland including lacrimal gland and the salivary gland, but there are many any questions about the onset and condition of a pathological condition progress.I focus attention on human T cell leukemia virus type I (HTLV-1).A difference was seen by clinical manifestations and a test result in HTLV-1(+) SS and the HTLV-1(-) SS.The T cell which infected HTLV-1 accumulated it around duct in the pathology organization of labial glands.Furthermore, participation in condition of a patient formation was suggested because I strongly developed chemokines receptor CCR4 paid the attention to as a new therapeutic drug of leukemia.

Research Products

• [Journal Article] A case of mantle cell lymphoma presenting as IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease (2015)
  • Author(s): Hayashi Y, Moriyama M, M Takashi, Goto Y, Kawano S, Ohta M, Tanaka A, Furukawa S, Hayashida JN, Kiyoshima T, Shimizu M, Chikui T, Nakamura S.
  • Journal Title: World J Surg Oncol Volume: 13 Issue: 1 Pages: 225-225
  • DOI: 10.1186/s12957-015-0644-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cytokine profiles contribute to understanding the pathogenic difference between Good syndrome and oral lichen planus: two case reports and literature review (2015)
  • Author(s): Maehara T, Moriyama M, Kawano S, Hayashida JN, Furukawa S, Ohta M, Tanaka A, Yamauchi M, Ohyama Y, Kiyoshima T, Nakamura S.
  • Journal Title: Medicine (Baltimore) Volume: 94(14) Issue: 14 Pages: e704-e704
  • DOI: 10.1097/md.0000000000000704
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis. (2015)
  • Author(s): Ohta M, Moriyama M, Goto Y, Kawano S, Tanaka A, Maehara T, Furukawa S, J Hayashida JN, Kiyoshima T, Shimizu M, Arinobu Y, Nakamura S.
  • Journal Title: World J Surg Oncol Volume: 13 Issue: 1 Pages: 67-67
  • DOI: 10.1186/s12957-015-0459-z
  • Peer Reviewed / Open Access
• [Journal Article] Saliva as a potential tool for diagnosis of dry mouth including Sjogren's syndrome. (2015)
  • Author(s): Ohyama K, Moriyama M et al.
  • Journal Title: Oral Dis Volume: 21(2) Issue: 2 Pages: 224-231
  • DOI: 10.1111/odi.12252
  • Peer Reviewed / Open Access
• [Journal Article] Clinical relevance of Kuttner tumour and IgG4-related dacryoadenitis and sialoadenitis. (2014)
  • Author(s): Furukawa S1, Moriyama M, Kawano S, Tanaka A, Maehara T, Hayashida JN, Goto Y, Kiyoshima T, Shiratsuchi H, Ohyama Y, Ohta M, Imabayashi Y, Nakamura S.
  • Journal Title: Oral Dis Volume: 21(2) Issue: 2 Pages: 257-62
  • DOI: 10.1111/odi.12259
  • Peer Reviewed / Open Access
• [Journal Article] Molecular analysis of fungal populations in patients with oral candidiasis using internal transcribed spacer region. (2014)
  • Author(s): Ieda S, Moriyama M, Takeshita T, Maehara T, Imabayashi Y, Shinozaki S, Tanaka A, Hayashida JN, Furukawa S, Ohta M,Yamashita Y, Nakamura S
  • Journal Title: PLoS One Volume: 30 Issue: 6 Pages: e101156-e101156
  • DOI: 10.1371/journal.pone.0101156
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz’s disease. (2014)
  • Author(s): Furukawa S, Moriyama M, Tanaka A, Maehara T, Tsuboi H, Iizuka M, Hayashida JN, Ohta M, Saeki T, Notohara K, Nakamura S.
  • Journal Title: Clinical Immnology Volume: 156 Issue: 1 Pages: 9-18
  • DOI: 10.1016/j.clim.2014.10.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] T helper subsets in Sjogren’s syndrome and IgG4-related dacryoadenitis and sialoadenitis: A critical review. (2013)
  • Author(s): Moriyama M, et al.
  • Journal Title: J Autoimmun. Volume: in press Pages: 81-88
  • DOI: 10.1016/j.jaut.2013.07.007
  • Peer Reviewed / Open Access
• [Presentation] The diagnostic utility of labial salivary gland biopsy in IgG4-related disease (2015)
  • Author(s): M. OHTA, M. MORIYAMA, S. FURUKAWA, Y. MIKAMI, A. TANAKA, T. MAEHARA,M. YAMAUCHI, N. ISHIGURO, J-N. HAYASHIDA, S. KAWANO, Y. OHYAMA,T. KIYOSHIMA, S. NAKAMURA
  • Organizer: 第63回国際歯科研究学会（JADR）総会・学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2015-10-30
  • Int'l Joint Research
• [Presentation] IgG4関連疾患の唾液腺病変 ～病態形成に関わるTh細胞の活性化機構～ (2015)
  • Author(s): 森山 雅文、田中 昭彦、前原 隆、古川 祥子、太田美穂、中村 誠司
  • Organizer: 第25回日本口腔内科学会学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2015-09-18
  • Invited
• [Presentation] シェーグレン症候群：診療ガイドラインについて 口腔病変の診断と治療 (2015)
  • Author(s): 森山 雅文、田中 昭彦、前原 隆、古川 祥子、太田美穂、中村 誠司
  • Organizer: 第24回日本シェーグレン症候群学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-18
  • Invited
• [Presentation] IL-33 secreted by M2 macrophage promotes the pathogenesis of IgG4-related disease (2015)
  • Author(s): Sachiko Furukawa, Masafumi Moriyama, Akihiko Tanaka, Takashi Maehara, Mana Iizuka, Hiroshi Tsuboi, Jun-Nosuke Hayashida, Miho Ohta, Masaki Yamauchi, Noriko Ishiguro, Hitoshi Nakashima, Takayuki Sumida, and Seiji Nakamura.
  • Organizer: The 13th international Symposium on Sjögren’s Syndrome
  • Place of Presentation: Norway
  • Year and Date: 2015-05-19
  • Int'l Joint Research
• [Presentation] DNA microarray analysis of submandibular glands in IgG4-related dacryoadenitis and sialoadenitis (2015)
  • Author(s): Miho Ohta, Masafumi Moriyama, Akihiko Tanaka, Takashi Maehara, Sachiko Furukawa, Hiroshi Tsuboi, Mana Iizuka, Shintaro Kawano, Jun-Nosuke Hayashida, Yumi Imabayashi, Masaki Yamauchi, Noriko Ishiguro, Takayuki Sumida, and Seiji Nakamura.
  • Organizer: The 13th international Symposium on Sjögren’s Syndrome
  • Place of Presentation: Norway
  • Year and Date: 2015-05-19
  • Int'l Joint Research
• [Presentation] IgG4 関連疾患（IgG4-RD）の病態形成における IL-33 の関与 (2015)
  • Author(s): 古川祥子, 森山雅文, 田中昭彦, 前原 隆, 林田淳之將, 太田美穂, 山内昌樹, 石黒乃理子, 中村誠司
  • Organizer: 第69回 NPO法人日本口腔科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-05-13
• [Presentation] シェーグレン症候群の病態形成におけるＴ細胞サブセットの関与 (2015)
  • Author(s): 森山 雅文、古川 祥子、田中 昭彦、前原 隆、太田 美穂、山内 昌樹、林田 淳之將、中村 誠司
  • Organizer: 第59回 日本リウマチ学会総会・学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-23
  • Invited
• [Presentation] IgG4 関連涙腺・唾液腺の疾患概念と免疫学的特徴 (2014)
  • Author(s): 森山 雅文、田中 昭彦、前原 隆、古川 祥子、中村 誠司
  • Organizer: 第24回 日本口腔内科学会・第27回 日本口腔診断学会 合同学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-09-20 – 2014-09-21
  • Invited