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Involvement of helper T cells in the pathogenesis of HTLV-1-related Sjogren's syndrome

Research Project

Project/Area Number 26861733
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

TANAKA AKIHIKO  九州大学, 大学病院, その他 (70615799)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsシェーグレン症候群 / HTLV-1 / Th / サイトカイン / ケモカイン
Outline of Final Research Achievements

Sjogren's syndrome (SS) is a chronic inflammatory disease mainly composed of the lymphocyte permeation of the exocrine gland including lacrimal gland and the salivary gland, but there are many any questions about the onset and condition of a pathological condition progress.I focus attention on human T cell leukemia virus type I (HTLV-1).A difference was seen by clinical manifestations and a test result in HTLV-1(+) SS and the HTLV-1(-) SS.The T cell which infected HTLV-1 accumulated it around duct in the pathology organization of labial glands.Furthermore, participation in condition of a patient formation was suggested because I strongly developed chemokines receptor CCR4 paid the attention to as a new therapeutic drug of leukemia.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2015 2014 2013

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 8 results,  Acknowledgement Compliant: 3 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results)

  • [Journal Article] A case of mantle cell lymphoma presenting as IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease2015

    • Author(s)
      Hayashi Y, Moriyama M, M Takashi, Goto Y, Kawano S, Ohta M, Tanaka A, Furukawa S, Hayashida JN, Kiyoshima T, Shimizu M, Chikui T, Nakamura S.
    • Journal Title

      World J Surg Oncol

      Volume: 13 Issue: 1 Pages: 225-225

    • DOI

      10.1186/s12957-015-0644-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cytokine profiles contribute to understanding the pathogenic difference between Good syndrome and oral lichen planus: two case reports and literature review2015

    • Author(s)
      Maehara T, Moriyama M, Kawano S, Hayashida JN, Furukawa S, Ohta M, Tanaka A, Yamauchi M, Ohyama Y, Kiyoshima T, Nakamura S.
    • Journal Title

      Medicine (Baltimore)

      Volume: 94(14) Issue: 14 Pages: e704-e704

    • DOI

      10.1097/md.0000000000000704

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis.2015

    • Author(s)
      Ohta M, Moriyama M, Goto Y, Kawano S, Tanaka A, Maehara T, Furukawa S, J Hayashida JN, Kiyoshima T, Shimizu M, Arinobu Y, Nakamura S.
    • Journal Title

      World J Surg Oncol

      Volume: 13 Issue: 1 Pages: 67-67

    • DOI

      10.1186/s12957-015-0459-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Saliva as a potential tool for diagnosis of dry mouth including Sjogren's syndrome.2015

    • Author(s)
      Ohyama K, Moriyama M et al.
    • Journal Title

      Oral Dis

      Volume: 21(2) Issue: 2 Pages: 224-231

    • DOI

      10.1111/odi.12252

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical relevance of Kuttner tumour and IgG4-related dacryoadenitis and sialoadenitis.2014

    • Author(s)
      Furukawa S1, Moriyama M, Kawano S, Tanaka A, Maehara T, Hayashida JN, Goto Y, Kiyoshima T, Shiratsuchi H, Ohyama Y, Ohta M, Imabayashi Y, Nakamura S.
    • Journal Title

      Oral Dis

      Volume: 21(2) Issue: 2 Pages: 257-62

    • DOI

      10.1111/odi.12259

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular analysis of fungal populations in patients with oral candidiasis using internal transcribed spacer region.2014

    • Author(s)
      Ieda S, Moriyama M, Takeshita T, Maehara T, Imabayashi Y, Shinozaki S, Tanaka A, Hayashida JN, Furukawa S, Ohta M,Yamashita Y, Nakamura S
    • Journal Title

      PLoS One

      Volume: 30 Issue: 6 Pages: e101156-e101156

    • DOI

      10.1371/journal.pone.0101156

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz’s disease.2014

    • Author(s)
      Furukawa S, Moriyama M, Tanaka A, Maehara T, Tsuboi H, Iizuka M, Hayashida JN, Ohta M, Saeki T, Notohara K, Nakamura S.
    • Journal Title

      Clinical Immnology

      Volume: 156 Issue: 1 Pages: 9-18

    • DOI

      10.1016/j.clim.2014.10.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] T helper subsets in Sjogren’s syndrome and IgG4-related dacryoadenitis and sialoadenitis: A critical review.2013

    • Author(s)
      Moriyama M, et al.
    • Journal Title

      J Autoimmun.

      Volume: in press Pages: 81-88

    • DOI

      10.1016/j.jaut.2013.07.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The diagnostic utility of labial salivary gland biopsy in IgG4-related disease2015

    • Author(s)
      M. OHTA, M. MORIYAMA, S. FURUKAWA, Y. MIKAMI, A. TANAKA, T. MAEHARA,M. YAMAUCHI, N. ISHIGURO, J-N. HAYASHIDA, S. KAWANO, Y. OHYAMA,T. KIYOSHIMA, S. NAKAMURA
    • Organizer
      第63回国際歯科研究学会(JADR)総会・学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IgG4関連疾患の唾液腺病変 ~病態形成に関わるTh細胞の活性化機構~2015

    • Author(s)
      森山 雅文、田中 昭彦、前原 隆、古川 祥子、太田美穂、中村 誠司
    • Organizer
      第25回日本口腔内科学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] シェーグレン症候群:診療ガイドラインについて 口腔病変の診断と治療2015

    • Author(s)
      森山 雅文、田中 昭彦、前原 隆、古川 祥子、太田美穂、中村 誠司
    • Organizer
      第24回日本シェーグレン症候群学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] IL-33 secreted by M2 macrophage promotes the pathogenesis of IgG4-related disease2015

    • Author(s)
      Sachiko Furukawa, Masafumi Moriyama, Akihiko Tanaka, Takashi Maehara, Mana Iizuka, Hiroshi Tsuboi, Jun-Nosuke Hayashida, Miho Ohta, Masaki Yamauchi, Noriko Ishiguro, Hitoshi Nakashima, Takayuki Sumida, and Seiji Nakamura.
    • Organizer
      The 13th international Symposium on Sjögren’s Syndrome
    • Place of Presentation
      Norway
    • Year and Date
      2015-05-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNA microarray analysis of submandibular glands in IgG4-related dacryoadenitis and sialoadenitis2015

    • Author(s)
      Miho Ohta, Masafumi Moriyama, Akihiko Tanaka, Takashi Maehara, Sachiko Furukawa, Hiroshi Tsuboi, Mana Iizuka, Shintaro Kawano, Jun-Nosuke Hayashida, Yumi Imabayashi, Masaki Yamauchi, Noriko Ishiguro, Takayuki Sumida, and Seiji Nakamura.
    • Organizer
      The 13th international Symposium on Sjögren’s Syndrome
    • Place of Presentation
      Norway
    • Year and Date
      2015-05-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IgG4 関連疾患(IgG4-RD)の病態形成における IL-33 の関与2015

    • Author(s)
      古川祥子, 森山雅文, 田中昭彦, 前原 隆, 林田淳之將, 太田美穂, 山内昌樹, 石黒乃理子, 中村誠司
    • Organizer
      第69回 NPO法人日本口腔科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] シェーグレン症候群の病態形成におけるT細胞サブセットの関与2015

    • Author(s)
      森山 雅文、古川 祥子、田中 昭彦、前原 隆、太田 美穂、山内 昌樹、林田 淳之將、中村 誠司
    • Organizer
      第59回 日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] IgG4 関連涙腺・唾液腺の疾患概念と免疫学的特徴2014

    • Author(s)
      森山 雅文、田中 昭彦、前原 隆、古川 祥子、中村 誠司
    • Organizer
      第24回 日本口腔内科学会・第27回 日本口腔診断学会 合同学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-20 – 2014-09-21
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2017-05-10  

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