Role of CCN family proteins during bone regeneration and bone regeneration therapy
| Project/Area Number |
26861734
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
MATSUSHITA Yuki 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (00713827)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | CCN3 / BMPアンタゴニスト / 骨再生 / BMP / CCNファミリー |
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| Outline of Final Research Achievements |
CCN3, a member of the CCN protein family, is a matricellular protein. We had elucidated that CCN3 is upregulated during bone regeneration and inhibits osteoblastogenesis. In this study, we investigated the relationship between CCN3 and other CCN family proteins or BMP antagonists.
We analyzed the expression levels of CCN1, CCN2, Noggin, Chordin, and Gremlin 1 by immunohistochemistry and Real time RT-PCR analysis using CCN3 mutant mice. Both Loss of function and gain of function of CCN3 induced fluctuation of CCN family proteins and BMP antagonists.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: Effect of neoadjuvant chemotherapy on local recurrence2014
Author(s)
Yanamoto S, Yamada S, Takahashi H, Naruse T, Matsushita Y, Ikeda H, Shiraishi T, Seki S, Fujita S, Ikeda T, Asahina I, Umeda M
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Journal Title
International Journal of Oncology
Volume: 44
Issue: 4
Pages: 1153-1162
DOI
Related Report
Peer Reviewed
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