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Role of CCN family proteins during bone regeneration and bone regeneration therapy

Research Project

Project/Area Number 26861734
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionNagasaki University

Principal Investigator

MATSUSHITA Yuki  長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (00713827)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsCCN3 / BMPアンタゴニスト / 骨再生 / BMP / CCNファミリー
Outline of Final Research Achievements

CCN3, a member of the CCN protein family, is a matricellular protein. We had elucidated that CCN3 is upregulated during bone regeneration and inhibits osteoblastogenesis. In this study, we investigated the relationship between CCN3 and other CCN family proteins or BMP antagonists.
We analyzed the expression levels of CCN1, CCN2, Noggin, Chordin, and Gremlin 1 by immunohistochemistry and Real time RT-PCR analysis using CCN3 mutant mice. Both Loss of function and gain of function of CCN3 induced fluctuation of CCN family proteins and BMP antagonists.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Granular cell ameloblastoma: Case report of a particular ameloblastoma histologically resembling oncocytoma.2015

    • Author(s)
      Matsushita Y, Fujita S, Kawasaki G, Rokutanda S, Yamashita K, Yanamoto S, Ikeda T and Umeda M
    • Journal Title

      Pathology international

      Volume: 65 Issue: 1 Pages: 43-47

    • DOI

      10.1111/pin.12231

    • NAID

      120006986294

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: Effect of neoadjuvant chemotherapy on local recurrence2014

    • Author(s)
      Yanamoto S, Yamada S, Takahashi H, Naruse T, Matsushita Y, Ikeda H, Shiraishi T, Seki S, Fujita S, Ikeda T, Asahina I, Umeda M
    • Journal Title

      International Journal of Oncology

      Volume: 44 Issue: 4 Pages: 1153-1162

    • DOI

      10.3892/ijo.2014.2289

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] CCN3 Protein Participates in Bone Regeneration as an Inhibitory Factor2015

    • Author(s)
      Matsushita Y, Yamaguchi A
    • Organizer
      41st Annual Moyers Symposium
    • Place of Presentation
      ミシガン大学(アメリカ)
    • Year and Date
      2015-03-06 – 2015-03-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 下顎に発生した顎骨中心性紡錘細胞癌の1例2014

    • Author(s)
      松下祐樹,柳本惣市,山田慎一,山下健太郎,市川陽子,藤田修一,池田 通,梅田正博
    • Organizer
      第59回日本口腔外科学会
    • Place of Presentation
      幕張メッセ(幕張)
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 下顎枝矢状分割術における口内法によるスクリュー固定とプレート固定の術後安定性の比較2014

    • Author(s)
      松下祐樹、中久木康一、小杉真智子、友松伸允、細木美佐、柚木泰広、園田 格、儀武啓幸、黒原一人、原田 清
    • Organizer
      第24回日本顎変形症学会
    • Place of Presentation
      アクロス福岡(福岡)
    • Year and Date
      2014-06-09 – 2014-06-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 下顎歯肉癌における骨浸潤と予後との関連2014

    • Author(s)
      松下祐樹,森ひとみ,柳本惣市,高橋英哲,鳴瀬智史,山田慎一,池田久住,白石剛士,南川 勉,渋谷恭之,古森孝英,朝比奈 泉,梅田正博
    • Organizer
      第68回日本口腔科学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2014-05-07 – 2014-05-09
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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