A morphological analysis of neural circuit for pain: a single neuron tracing study with viral vectors.
| Project/Area Number |
26861739
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
Ohno Sachi 鹿児島大学, 医歯学域附属病院, 助教 (00535693)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 三叉神経脊髄路核 / 痛覚神経回路 / 単一ニューロン標識法 / 三叉神経脊髄路核尾側亜核 / シンドビスウイルスベクター |
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| Outline of Final Research Achievements |
The caudal part of trigeminal nucleus (Sp5C) is involved in nociceptive information processing from the head and orofacial regions. Sp5C neurons project to a number of regions within the thalamus, periaqueductal gray and hypothalamus. These projections are thought to be involved in cardiovascular and visceral modifications which are associated with noxious stimulation. In the present study, we investigated axonal and dendritic arborizations of single Sp5C neurons in rats with single neuron labeling method. The results suggest that a few Sp5C neurons projects to thalamus directly, but most Sp5C neurons innervates within Sp5 or near regions.
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Report
(4 results)
Research Products
(4 results)
