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Development of cancer immunotherapy using nanogel

Research Project

Project/Area Number 26861741
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

ADACHI TETSUYA  京都府立医科大学, 医学部附属病院, 専攻医 (10613573)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsナノゲル / VEGF / ドラッグデリバリーシステム / MDSC / VEGF-A
Outline of Final Research Achievements

RNAi(RNA interference) enables potent and specific gene silencing, potentially offering useful means for treatment of cancers. However, safe and efficient drug delivery systems (DDS) that are appropriate for tumor microenvironment delivery of siRNA have rarely been established, hindering clinical application of RNAi technology to cancer therapy. We develop cholesterol-bearing cycloamylose with spermine group (CH-CA-Spe) , and shown its validity as a novel DDS for siRNA.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Biomaterial force induces the growth factor production in human periodontal ligament-derived cells2016

    • Author(s)
      Ichioka H, Yamamoto T, Yamamoto K, Honjo K, Adachi T, Oseko F, Mazda O, Kanamura N, Kita M.
    • Journal Title

      Odontology

      Volume: 104 Pages: 27-34

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silicon Nitride Bioceramics Induce Chemically Driven Lysis in Porphyromonas Gingivalis.2016

    • Author(s)
      Pezzotti G, Bock RM, McEntire BJ, Jones E, Boffelli M, Zhu W, Baggio G, Boschetto F, Puppulin L, Adachi T, Yamamoto T, Kanamura N, Marunaka Y, Bal BS
    • Journal Title

      Langmuir

      Volume: 32 Issue: 12 Pages: 3024-035

    • DOI

      10.1021/acs.langmuir.6b00393

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Vibrational algorithms for quantitative crystallographic analyses of hydroxyapatite-based biomaterials: II, application to decayed human teeth.2015

    • Author(s)
      Adachi T, Pezzotti G, Yamamoto T, Ichioka H, Boffelli M, Zhu W, Kanamura N.
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 407 Issue: 12 Pages: 3343-56

    • DOI

      10.1007/s00216-015-8539-z

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vibrational algorithms for quantitative crystallographic analyses of hydroxyapatite-based biomaterials: I, Theoretical foundations2015

    • Author(s)
      Pezzotti G, Zhu W, Boffelli M, AdachiT, Ichioka H, Yamamoto T, MARUNAKA Y, Kanamura N
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 407( Issue: 12 Pages: 3325-3342

    • DOI

      10.1007/s00216-015-8472-1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a dental pulp-derived cell sheet cultured on amniotic membrane substrate.2015

    • Author(s)
      Honjo K, Yamamoto T, Adachi T, Amemiya T, Mazda O, Kanamura N, Kita M.
    • Journal Title

      Bio-medical materials and engineering

      Volume: 25 Issue: 2 Pages: 203-212

    • DOI

      10.3233/bme-151270

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cycloamylose-Nanogel DDS-mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment2014

    • Author(s)
      H. Fujii, M. Shin-Ya, S. Takeda, Y. Hashimoto, S. Mukai, S. Sawada, T. Adachi, K. Akiyoshi, T. Miki, O. Mazda
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 12 Pages: 1616-1625

    • DOI

      10.1111/cas.12547

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Surface modulation of silicon nitride ceramics for dental implant2016

    • Author(s)
      TETSUYA ADACHI
    • Organizer
      The 45th American Association for Dental Research / 40th Canadian Association for Dental Research Annual Meeting & Exhibition
    • Place of Presentation
      Los Angeles
    • Year and Date
      2016-03-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reduction of oxidative stress by Astaxathin in lipopolysaccharide-treated human gingival fibroblasts2015

    • Author(s)
      Tetsuya Adachi,Toshiro Yamamoto, Ken-ichi Honjo, Hiroaki Ichioka, Kenta Yamamoto, Fumishige Oseko, Masakazu Kita, Narisato Kanamura.
    • Organizer
      93rd General Session & Exhibition of the IADR/44th Annual Meeting & Exhibition of the AADR
    • Place of Presentation
      ボストン市(米国)
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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