| Project/Area Number |
26861741
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
ADACHI TETSUYA 京都府立医科大学, 医学部附属病院, 専攻医 (10613573)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ナノゲル / VEGF / ドラッグデリバリーシステム / MDSC / VEGF-A |
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| Outline of Final Research Achievements |
RNAi（RNA interference） enables potent and specific gene silencing, potentially offering useful means for treatment of cancers. However, safe and efficient drug delivery systems (DDS) that are appropriate for tumor microenvironment delivery of siRNA have rarely been established, hindering clinical application of RNAi technology to cancer therapy. We develop cholesterol-bearing cycloamylose with spermine group (CH-CA-Spe) , and shown its validity as a novel DDS for siRNA.
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