Development of cancer immunotherapy using nanogel

• Project/Area Number: 26861741
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: ADACHI TETSUYA 京都府立医科大学, 医学部附属病院, 専攻医 (10613573)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ナノゲル / VEGF / ドラッグデリバリーシステム / MDSC / VEGF-A

Outline of Final Research Achievements

RNAi（RNA interference） enables potent and specific gene silencing, potentially offering useful means for treatment of cancers. However, safe and efficient drug delivery systems (DDS) that are appropriate for tumor microenvironment delivery of siRNA have rarely been established, hindering clinical application of RNAi technology to cancer therapy. We develop cholesterol-bearing cycloamylose with spermine group (CH-CA-Spe) , and shown its validity as a novel DDS for siRNA.

Research Products

• [Journal Article] Biomaterial force induces the growth factor production in human periodontal ligament-derived cells (2016)
  • Author(s): Ichioka H, Yamamoto T, Yamamoto K, Honjo K, Adachi T, Oseko F, Mazda O, Kanamura N, Kita M.
  • Journal Title: Odontology Volume: 104 Pages: 27-34
  • Peer Reviewed
• [Journal Article] Silicon Nitride Bioceramics Induce Chemically Driven Lysis in Porphyromonas Gingivalis. (2016)
  • Author(s): Pezzotti G, Bock RM, McEntire BJ, Jones E, Boffelli M, Zhu W, Baggio G, Boschetto F, Puppulin L, Adachi T, Yamamoto T, Kanamura N, Marunaka Y, Bal BS
  • Journal Title: Langmuir Volume: 32 Issue: 12 Pages: 3024-035
  • DOI: 10.1021/acs.langmuir.6b00393
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vibrational algorithms for quantitative crystallographic analyses of hydroxyapatite-based biomaterials: II, application to decayed human teeth. (2015)
  • Author(s): Adachi T, Pezzotti G, Yamamoto T, Ichioka H, Boffelli M, Zhu W, Kanamura N.
  • Journal Title: Analytical and Bioanalytical Chemistry Volume: 407 Issue: 12 Pages: 3343-56
  • DOI: 10.1007/s00216-015-8539-z
  • Peer Reviewed
• [Journal Article] Vibrational algorithms for quantitative crystallographic analyses of hydroxyapatite-based biomaterials: I, Theoretical foundations (2015)
  • Author(s): Pezzotti G, Zhu W, Boffelli M, AdachiT, Ichioka H, Yamamoto T, MARUNAKA Y, Kanamura N
  • Journal Title: Analytical and Bioanalytical Chemistry Volume: 407( Issue: 12 Pages: 3325-3342
  • DOI: 10.1007/s00216-015-8472-1
  • Peer Reviewed
• [Journal Article] Evaluation of a dental pulp-derived cell sheet cultured on amniotic membrane substrate. (2015)
  • Author(s): Honjo K, Yamamoto T, Adachi T, Amemiya T, Mazda O, Kanamura N, Kita M.
  • Journal Title: Bio-medical materials and engineering Volume: 25 Issue: 2 Pages: 203-212
  • DOI: 10.3233/bme-151270
  • Peer Reviewed / Open Access
• [Journal Article] Cycloamylose-Nanogel DDS-mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment (2014)
  • Author(s): H. Fujii, M. Shin-Ya, S. Takeda, Y. Hashimoto, S. Mukai, S. Sawada, T. Adachi, K. Akiyoshi, T. Miki, O. Mazda
  • Journal Title: Cancer Science Volume: 105 Issue: 12 Pages: 1616-1625
  • DOI: 10.1111/cas.12547
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Surface modulation of silicon nitride ceramics for dental implant (2016)
  • Author(s): TETSUYA ADACHI
  • Organizer: The 45th American Association for Dental Research / 40th Canadian Association for Dental Research Annual Meeting & Exhibition
  • Place of Presentation: Los Angeles
  • Year and Date: 2016-03-16
  • Int'l Joint Research
• [Presentation] Reduction of oxidative stress by Astaxathin in lipopolysaccharide-treated human gingival fibroblasts (2015)
  • Author(s): Tetsuya Adachi,Toshiro Yamamoto, Ken-ichi Honjo, Hiroaki Ichioka, Kenta Yamamoto, Fumishige Oseko, Masakazu Kita, Narisato Kanamura.
  • Organizer: 93rd General Session & Exhibition of the IADR/44th Annual Meeting & Exhibition of the AADR
  • Place of Presentation: ボストン市(米国)
  • Year and Date: 2015-03-11 – 2015-03-14