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Investigation of involvement of the limbic system on atypical odontalgia

Research Project

Project/Area Number 26861743
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

Sago Teppei  九州歯科大学, 歯学部, 助教 (80710574)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords非定型歯痛 / 特発性顔面痛 / 大脳辺縁系 / 非定型顔面痛 / 慢性疼痛 / 情動ストレス
Outline of Final Research Achievements

Changes in sympathetic nerve activity during atypical toothache (atypical odontalgia, AO) stress loading were examined. Activity evaluation of autonomic nerve was done by Fourier transform of RR interval variation of electrocardiogram and spectral analysis. There was no difference in sympathetic nervous activity between the AO group and the control group in the absence of stress load. Similarly, sympathetic hyperactivity after physical stress did not differ between the two groups. However, in AO group, there was greater sympathetic hyperactivity than emotional stress.As a result of comparing the first half and second half at the time of emotional stress loading, the control group showed a significant decrease in the latter half, whereas the AO group showed a decrease. There was inferred adaptive dysfunction to emotional stress by the prefrontal cortex in the AO group.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Prostanoid-dependent spontaneous pain and PAR2-dependent mechanical pain following oral mucosal trauma: involvement of TRPV1, TRPA1 and TRPV42017

    • Author(s)
      Misa Ito, Kentaro Ono, Suzuro Hitomi, Tomotaka Nodai, Teppei Sago, Kiichiro Yamaguchi, Nozomu Harano, Kaori Gunjigake, Ryuji Hosokawa, Tatsuo Kawamoto, Kiyotoshi Inenaga
    • Journal Title

      Molecular Pain

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 情動ストレスが慢性化した頭頸筋・筋膜痛患者の交感神経活動に与える影響2016

    • Author(s)
      椎葉俊司,布巻昌仁,左合徹平,原野望,吉田充広,坂本和美,小野堅太郎,北村知明,鱒見進一
    • Journal Title

      日本口腔顔面痛学会雑誌

      Volume: 8 Pages: 7-10

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 抗がん薬併用口内炎モデルラットにおける口内炎疼痛のメカニズム2015

    • Author(s)
      山口喜一郎,原野望,中津由博,左合徹平,布巻昌仁,椎葉俊司,渡邉誠之
    • Organizer
      日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      学術総合センター
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] ケタミンの抗うつ効果の検討2014

    • Author(s)
      長谷川 円,左合徹平,多田 幸代,中津 由博,山口 喜一郎,長行事 由貴,原野 望,布巻 昌仁,椎葉 俊司,渡邉 誠之
    • Organizer
      日本歯科麻酔学会
    • Place of Presentation
      新潟
    • Year and Date
      2014-10-11 – 2014-10-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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