Establishing of the a rat model of bisphosphonate-related osteonecrosis and development of novel treatment with teriparatide.
| Project/Area Number |
26861744
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | MRONJ / テリパラチド / 顎骨壊死 / LPS / ビスフォスフォネート / ＭＲＯＮＪ / ＢＲＯＮＪ / BRONJ |
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| Outline of Final Research Achievements |
As a cause of the medication related osteonecrosis of the jaw bone (MRONJ), the participation of oral bacteria had been shown, but the possibility that the Lipopolysaccharide (LPS) of the gram-negative bacillus was the causes was shown in this study. In addition, it was only the animal model which assumed injectable BP patient, but succeeded in the development of the model rat which assumed internal use BP patient. In addition, the decrease in osteonecrosis area and the induced new bone formation were recognized by using teriparatide for MRONJ model rat. Usefulness of teriparatide for the treatment of MRONJ was shown.
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Report
(5 results)
Research Products
(9 results)
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[Journal Article] LIPOPOLYSACCHARIDE AGGRAVATES BISPHOSPHONATE- INDUCED OSTEONECROSIS IN RATS.2015
Author(s)
Sakaguchi, O., Kokuryo, S., Tsurushima, H., Tanaka, J., Habu, M., Uehara, M., Nishihara, T., Tominaga, K
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Journal Title
International Journal of Oral and Maxillofacial Surgery
Volume: 44
Pages: 528-34
Related Report
Peer Reviewed / Open Access
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[Presentation] Novel induction of oral bisphosphonate-induced osteonecrosis in ovariectomized rats.2015
Author(s)
Tanaka,J.,Kokuryo,S.,Yoshiga,D.,Tsurushima,M.,Sakaguchi,O.,Nishihara,at.,Yoshioka,I.and Tominaga,K.
Organizer
Asia-Pacific Conference in Fukuoka
Place of Presentation
北九州
Year and Date
2015-01-23
Related Report
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