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Anxiolytic actions of food intake : roles of activation of the PrRP neuron -oxytocin neuron pathway

Research Project

Project/Area Number 26861747
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionJichi Medical University

Principal Investigator

Yamashita Masako  自治医科大学, 医学部, 臨床助教 (70569946)

Research Collaborator ONAKA Tatsushi  自治医科大学, 医学部 生理学講座 神経脳生理学部門
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsオキシトシン / プロラクチン産生ニューロン / 摂食 / ストレス / プロラクチン放出ペプチド産生ニューロン
Outline of Final Research Achievements

Food intake activated oxytocin neurones in the hypothalamus. Activation of oxytocin neurons in the hypothalamus in response to food intake was impaired in PrRP-deficient mice. Food intake facilitates peripheral CCK release.Peripheral administration of CCK activates oxytocin neurons. Activation of oxytocin neurons following peripheral CCK administration was also significantly reduced in PrRP-deficient mice. Oxytocin neurons have been shown to have anti-stress actions. Activation of the PrRP neuron-oxytocin neuron pathway following food intake may contribute to anxiolitic actions of food intake.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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