Explication of the mechanism and new therapy in refractory chronic orofacial pain

• Project/Area Number: 26861756
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tsurumi University
• Principal Investigator: YAMAMOTO Toru 鶴見大学, 歯学部, 助教 (20707335)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 口腔顔面痛 / エンドセリン / 神経障害性疼痛 / 疼痛研究 / 口腔顎顔面領域

Outline of Final Research Achievements

We investigated the effect of endothelin in orofacial pain. In the present study, the injection of endothelin-1(ET-1) at whisker pad prolonged the duration of the pain-related behavior. This result suggests that endothelin has some sort of effect for orofacial pain. Subsequently, we prepared the neuropathic pain model rat(transection・ligation).