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Elucidation of mechanisms maintaining and regenerating secretory function of water in salivary glands that occurs mastication

Research Project

Project/Area Number 26861774
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Mizumachi Mariko  東京医科歯科大学, 歯学部, 非常勤講師 (00706955)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords唾液腺 / AQP5 / 咀嚼 / アクアポリン
Outline of Final Research Achievements

We investigated alteration of water secretory function in salivery glands that occurs change and recovery of mastication. In this study, we elucidated that AQP5 was detected on the apical membrane of acinar cells, inter cellular secretory canaliculi of acinar cell in sabmandibular salivary gland in the masticatory hypofunciton group, but the staining appeared to be less prominent than that in the control group. In the masticatory recovery group, expression of AQP5 was observed on that area again. These result.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Expression of glucose-dependent insulinotropic polypeptide and its receptor in the rat major salivary glands2014

    • Author(s)
      Jutiporn Privatananupunt, Ippei Watari, Katarzyna Anna Podyma-Inoue, Mariko Kubono, Takashi Ono
    • Journal Title

      Acta Histochem

      Volume: 116(4) Issue: 4 Pages: 545-550

    • DOI

      10.1016/j.acthis.2013.11.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Degeneration of fungiform and circumvallate papillae following molar extraction in rats.2014

    • Author(s)
      Hsu JC, Watari I, Ono R, Privatananupunt J, Mizumachi-Kubono M, Honda K, Ishida Y, Ono T
    • Journal Title

      Acta Odontol Scand.

      Volume: 72 (8) Issue: 8 Pages: 880-6

    • DOI

      10.3109/00016357.2014.920105

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Unilateral nasal obstruction effects taste cell in circumvallate papillae in rats.2016

    • Author(s)
      Ershu Ren, Ippei Watari, Jui-Chin Hsu, Rieko Ono, Emiina Wakasugi-Aoyama, Mariko Mizumachi-Kubono, Katarzyna Anna Podyma-Inoue, Tetsuro Watabe, Takashi Ono
    • Organizer
      International Symposium on Olfaction and Taste, ISOT
    • Place of Presentation
      パシフィコ横浜(〒220-0012 横浜市西区みなとみらい1-1-1)
    • Year and Date
      2016-06-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of GLP-1 and GLP-1 receptor in rat circumvallate papollae during growth period2016

    • Author(s)
      Beauboeuf Roody, Ippei Watari, Jui-Chin Hsu, Mariko Mizumachi-Kubono, Katarzyna Anna Podyma-Inoue, Tetsuro Watabe, Takashi Ono
    • Organizer
      International Symposium on Olfaction and Taste, ISOT
    • Place of Presentation
      パシフィコ横浜(〒220-0012 横浜市西区みなとみらい1-1-1)
    • Year and Date
      2016-06-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Degeneration of fungiform and circumvallate papillae following molar extraction and unilateral nasal obstruction in rats2016

    • Author(s)
      Jui-Chin Hsu, Ippei Watari, Rieko Ono, Mariko Mizumachi-Kubono, Yukiha Funaki, Satoshi Kokai, Takashi Ono
    • Organizer
      17th International Symposium on Olfaction and Taste
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-06-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Expression of GLP-1 and GLP-1 receptor in rat's circumvallate papilla during growth period2016

    • Author(s)
      Beauboeuf Roody, Ippei Watari, Jui-Chin Hsu, Mariko Mizumachi-Kubono, Katarzyna Anna Podyma-Inoue, Tetsuro Watabe, Takashi Ono
    • Organizer
      17th International Symposium on Olfaction and Taste
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-06-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Unilateral nasal obstruction effects taste cell in circumvallate papillae in rats2016

    • Author(s)
      Ershu Ren, Ippei Watari, Jui-Chin Hsu, Mariko Mizumachi-Kubono, Katarzyna Anna Podyma-Inoue, Tetsuro Watabe, Takashi Ono
    • Organizer
      17th International Symposium on Olfaction and Taste
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-06-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2018-03-22  

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