Correlation between brain activity and articulatory movement during speech in cleft lip/palate

• Project/Area Number: 26861776
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Inoue-Arai Maristela Sayuri 東京医科歯科大学, 医歯(薬)学総合研究科, 非常勤講師 (00707789)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: cleft lip and palate / fMRI / MRI movie / overt artiiculation / covert articulation / overt articulation

Outline of Final Research Achievements

The overall goal of this study was undertaken to demonstrate the importance of the versatile evaluation of articulatory function in cleft lip and palate (CLP) from central and peripheral perspectives, using fMRI and MRI movie technique.
Following results were obtained; the peripheral movements of the articulators and cortical activation were similar in brain activation pattern between subjects with and without CLP, however the activation patterns for articulation was different between subjects with CLP with compensatory misarticulation, however is not related with the presence or type of CLP.

Research Products

• [Journal Article] A pilot study on characterization of articulatory movements during fricative /s/ sound in an anterior open-bite subject: A tooth-visualized 3-T magnetic resonance imaging video evaluation (2015)
  • Author(s): Kulthida Nunthayanon, Ei-ichi Honda, Kazuo Shimazaki, Hiroko Ohmori, Maristela Sayuri Inoue-Arai, Tohru Kurabayashi, Takashi Ono
  • Journal Title: Journal of the World Federation of Orthodontists Volume: 4（2） Issue: 2 Pages: 71-77
  • DOI: 10.1016/j.ejwf.2015.03.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differences in Velopharyngeal Structure during Speech among Asians Revealed by 3-Tesla Magnetic Resonance Imaging Movie Mode (2015)
  • Author(s): Kulthida Nunthayanon, Ei-ichi Honda, Kazuo Shimazaki, Hiroko Ohmori, Maristela Sayuri Inoue-Arai, Tohru Kurabayashi, Takashi Ono
  • Journal Title: BioMed Research International Volume: 2015（2015） Pages: 1-8
  • DOI: 10.1155/2015/126264
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Use of an advanced 3-T MRI movie to investigate articulation. (2015)
  • Author(s): Kulthida Nunthayanon, Ei-ichi Honda, Kazuo Shimazaki, Hiroko Ohmori, Maristela Sayuri Inoue-Arai, Tohru Kurabayashi, Takashi Ono
  • Journal Title: Oral surgery, oral medicine, oral pathology and oral radiology Volume: 119(6) Issue: 6 Pages: 684-694
  • DOI: 10.1016/j.oooo.2015.03.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Use of an Advanced 3-T MRI Movie to Investigate Articulation (2014)
  • Author(s): Nunthayanon K, Honda E, Shimazaki K, Ohmori H, Inoue-Arai MS,Kurabayashi T, Ono T.
  • Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology (OOOO) Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of articulatory movements during fricative /s/ sound in an anterior open bite subject: a tooth-visualized 3-T MRI movie study (2014)
  • Author(s): Nunthayanon K, Honda E, Shimazaki K, Ohmori H, Inoue-Arai MS,Kurabayashi T, Ono T.
  • Journal Title: Journal of World Federation of Orthodontists (JWFO) Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Differences in Velopharyngeal structure during speech among Asians revealed by 3-Tesla magnetic resonance imaging movie mode (2014)
  • Author(s): Nunthayanon K, Honda E, Shimazaki K, Ohmori H, Inoue-Arai MS,Kurabayashi T, Ono T.
  • Journal Title: BioMed Research International "Cleft Palate, Interdisciplinary Diagnosis, and Treatment" Volume: -
  • Peer Reviewed / Open Access
• [Presentation] Comparison of fricative sound between anterior open bite and normal subjects: 3T MRI movie method. (2014)
  • Author(s): Nunthayanon K, Honda E, Ohmori H, Inoue-Arai MS, Shimazaki K, Kurabayashi T, Ono T.
  • Organizer: The 73rd Annual Meeting of the Japanese Orthodontic Society (Chiba, Japan)
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2014-10-20 – 2014-10-22
• [Presentation] 嚥下時舌運動の経時的評価に対するMRI movieの有用性. (2014)
  • Author(s): エクプラチャヤクン・イサリア, 高田潤一, 井上マリステラ小百合, 宮本 順, 誉田栄一, 倉林 亨, 森山啓司
  • Organizer: The 73rd Annual Meeting of the Japanese Orthodontic Society (Chiba, Japan)
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2014-10-20 – 2014-10-22