The control of FGFR signal by heparan sulfate chain degrading enzyme results in altered closure of cranial suture in Apert mouse model
| Project/Area Number |
26861777
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUZUKI HIROYUKI 東京医科歯科大学, 歯学部附属病院, 非常勤講師 (70634492)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | Apert症候群 / Aper症候群 / 先天異常症候群 / Ａｐｅｒｔ症候群 |
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| Outline of Final Research Achievements |
Apert syndrome is characterized by craniosynostosis and syndactyly, and is predominantly caused by point mutation of either S252W or P253Rin the fibroblast growth factor receptor (FGFR) 2 gene. These mutation cause activation of FGFR2 depending on ligand binding. Recently, an Apert syndrome mouse model(FGFR2 knock-in mouse model) showed phenotypes similar to those of Apert syndrome patients.
In this study, we plan to investigate the phenotypes of Apert syndrome mouse model to clarify the pathogenic mechanism of Apert syndrome. Moreover, we analyze the effects of FGF signal control by heparan sulfate (HS) chains degrading enzyme craniosynostosis to improve new noninvasive therapeutic approach. We planned and performed the experiment that we operated HS chain degrading enzyme on coronal suture of mouse at a fetal age by gel beads as a carrier material locally. Our results suggest that HS chain degrading enzyme could be a useful tool for treating craniosynostosys in Apert syndrome.
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Report
(4 results)
Research Products
(3 results)
