| Project/Area Number |
26861779
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthodontics/Pediatric dentistry
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 舌 / 一次繊毛 |
|---|
| Outline of Final Research Achievements |
In this study, we investigated the role of the primary cilia in tongue development. Mice with neural crest-derived cell conditional mutation of the primary cilia protein, Ofd1, showed notable tongue abnormalities, and the primary cilia were significantly shortened. However, mice with epithelium-, mesoderm- and endoderm-derived cell conditional mutation of Ofd1 exhibited no significant tongue abnormalities, suggesting that the primary cilia in neural crest-derived cells play a critical role in tongue development.
|
