| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The aims of the present study were to evaluate if the hypoxia is induced at the pressured periodontal ligament in response to experimental tooth movement, and if ER stress and the subsequent stress response appears associated with hypoxia. Hypoxic area was determined by pimonidazole staining. ER stress was evaluated by the distribution of Xbp1 and Chop mRNA. We found that pimonidazole staining was specifically evident at the bone-forming regions and the pressured periodontal ligaments. We also found that Xbp1, Chop and ATF4 mRNA expression was specifically detected in osteoblasts and PDL cells in the pressured side. Further evaluation would clarify the close association between the hypoxia and the ER stress during bone formation and during orthodontic tooth movement. Understanding such celluar and molecular mechanism of ER stress in orthodontic tooth movement could contribute a lot to minimize the unwanted and/or iatrogenic response during orthodontic treatment.
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