Clinical evaluation and action mechanism elucidation of systemic infection prevention program using 3DS

• Project/Area Number: 26861789
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: NIIZATO Noriko 広島大学, 医歯薬保健学研究科(歯), 助教 (10508104)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ３ＤＳ / 口腔粘膜炎 / 小児がん治療 / 口腔内除菌システム / 免疫抑制 / 3DS / 造血幹細胞移植 / 全身的感染予防 / 口腔内除菌 / 感染予防

Outline of Final Research Achievements

We have created a new criterion for evaluating the oral mucosal status of children undergoing hematopoietic stem cell transplant with myeloablative treatment.After that, we devised a systemic infection prevention program using 3DS and showed that clinical application of 3DS can mitigate mucositis.
Then we clarified the mechanism by which 3DS relieves mucositis.
And we found that permanent teeth defects, dwarf teeth and morphologically abnormal teeth occur frequently with chemotherapy and radiotherapy treatments.