Analysis of intercellular network mechanism in tissue repair and homeostatic maintenance by dental pulp cells
| Project/Area Number |
26861790
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 乳歯 / 歯髄細胞 / 乳歯歯髄細胞 / 組織修復 |
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| Outline of Final Research Achievements |
Dental pulp has the ability to form dentin and self-repair against various external stimuli such as dental caries and trauma. Various cells are involved in maintaining and regenerating the homeostasis of the pulp, and it is thought that the induction mechanism of mesenchymal stem cells and vascular endothelial cells is involved. Molecular stromal cell derived factor 1α (SDF-1) which we have noted is known to act on mesenchymal stem cells and vascular endothelial precursor cells. In this study, we clarified the possibility that SDF-1 is involved in pulp repair and maintenance of homeostasis using intercellular signal transduction through molecules such as FGF-2, TGF-β, ALK 5 .
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Recruitment of mesenchymal stem cells by stromal cell-derived factor 1α in pulp cells from deciduous teeth2015
Author(s)
Yuki Akazawa, Tomokazu Hasegawa, Yoshitaka Yoshimura, Naoyuki Chosa, Takeyoshi Asakawa, Kimiko Ueda, Asuna Sugimoto, Takamasa Kitamura, Hiroshi Nakazgawa, Akira Ishisaki, Tsutomu Iwamoto
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Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Volume: 36
Pages: 442-448
Related Report
Peer Reviewed
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[Journal Article] Recruiyment of mesenchymal stem cells by stromal cell-derived factor 1 α in pulp cells from deciduous teeth2015
Author(s)
Yuki Akazawa, Tomokazu Hasegawa, Yoshitaka Yoshimura, Naoyuki Chousa, Takeyoshi Asakawa, Kimiko Ueda, Asuna Sugimoto, Takamasa Kitamura, Hiroshi Nakagawa, Akira Ishisaki, and Tsutomu Iwamoto
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Journal Title
Int J Mol Med 2015年4月2日accepted
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Molecular mechanisms of SDF-1α suppression by FGF2 in dental pulp cells2016
Author(s)
Yuki Akazawa, Tomokazu Hasegawa, Yoshitaka Yoshimura, Naoyuki Chosa, Takeyoshi Asakawa, Asuna Sugimoto, Takamasa Kitamura, Kimiko Ueda, Keita Kawarabayashi, Akira Ishisaki, Riku Takahashi, Yuto Suehiro, Tsutomu Iwamoto
Organizer
第１０回アジア小児歯科学会
Place of Presentation
東京ドームホテル（東京都文京区）
Year and Date
2016-05-26
Related Report
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