Do allergies have a risk factor for bone loss

• Project/Area Number: 26861793
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Kyushu University
• Principal Investigator: Ouchi Masahiro 九州大学, 大学病院, その他 (70707182)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: アレルギー / 骨代謝 / 破骨細胞

Outline of Final Research Achievements

I researched on the theme of "Do allergies have a risk factor for bone loss" in this challenge. Using the allergy mouse model, an increase of inflammatory cytokine in systematic allergic initiation and long term bone loss has been suggested that caused by allergy. In addition, studied cytokines and lipid mediators involved in bone loss mechanism by allergies, a new understanding to the relationship between allergy and bone to develop, and may find a treatment target from a new point of view.