Effect of functional hypofunction following botulinum neurotoxin injections on craniofacial growth and development of masticatory function.
| Project/Area Number |
26861795
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
UTSUMI Dai 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (80622604)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯学 / マウス / ボツリヌストキシン / 歯科矯正学 / 咀嚼運動メカニクス / ハイスピードカメラ |
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| Outline of Final Research Achievements |
In the present study, we use the mice model for evaluating the effect of muscle hypofunction following botulinum neurotoxin injections on the craniofacial morphology and masticatory function.Three-dimensional jaw movements and EMG of the masseter and temporalis muscles were recorded while mice were chewing.
In the hypofunction group, muscle activities and jaw movement trajectoryies were changed. We found that the masseter plays an important role in stabilizing the grinding path, and the temporalis plays a major role in retracting the mandible more posteriorly in the early phase of closing, extending the grinding path. Furthermore, these results suggest that a part of functional disorders affect other coordination of mastication.
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Report
(4 results)
Research Products
(8 results)
