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Effect of functional hypofunction following botulinum neurotoxin injections on craniofacial growth and development of masticatory function.

Research Project

Project/Area Number 26861795
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

UTSUMI Dai  長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (80622604)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords歯学 / マウス / ボツリヌストキシン / 歯科矯正学 / 咀嚼運動メカニクス / ハイスピードカメラ
Outline of Final Research Achievements

In the present study, we use the mice model for evaluating the effect of muscle hypofunction following botulinum neurotoxin injections on the craniofacial morphology and masticatory function.Three-dimensional jaw movements and EMG of the masseter and temporalis muscles were recorded while mice were chewing.
In the hypofunction group, muscle activities and jaw movement trajectoryies were changed. We found that the masseter plays an important role in stabilizing the grinding path, and the temporalis plays a major role in retracting the mandible more posteriorly in the early phase of closing, extending the grinding path. Furthermore, these results suggest that a part of functional disorders affect other coordination of mastication.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) Remarks (2 results)

  • [Journal Article] Effects of feeding a soft diet and subsequent rehabilitation on the development of the masticatory function2015

    • Author(s)
      A. Fujishita, Y. Koga, D. Utsumi, A. Nakamura, T. Yoshimi, N. Yoshida
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 42 (4) Issue: 4 Pages: 266-274

    • DOI

      10.1111/joor.12248

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] マウスにおける閉口相での咬筋および側頭筋の協調運動のメカニズムについて2015

    • Author(s)
      吉見知子,森内絵美,藤下あゆみ,中村 文,内海 大,吉見圭子,古賀義之,蔡 吉陽,吉田教明
    • Organizer
      第74回日本矯正歯科学会大会
    • Place of Presentation
      福岡県福岡市マリンメッセ福岡
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] ハイスピードカメラと3DマイクロX線CTを用いた小動物6自由度顎運動解析システムの構築2015

    • Author(s)
      森内絵美,吉見知子,藤下あゆみ,中村 文,内海 大,古賀義之,吉田教明
    • Organizer
      第74回日本矯正歯科学会大会
    • Place of Presentation
      福岡県福岡市マリンメッセ福岡
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] ボツリヌストキシン注入後の咀嚼筋機能低下によるマウス咀嚼運動の変化2015

    • Author(s)
      吉見知子, 森内絵美, 藤下あゆみ, 中村 文, 内海 大, 吉見圭子, 古賀義之, 蔡 吉陽, 吉田教明
    • Organizer
      第54回日本顎口腔機能学会学術大会
    • Place of Presentation
      鹿児島県鹿児島市鹿児島大学郡元キャンパス 学習交流プラザ
    • Year and Date
      2015-04-18 – 2015-04-19
    • Related Report
      2014 Research-status Report
  • [Presentation] ボツリヌストキシン注入後の咀嚼筋機能低下によるマウス咀嚼運動の変化2015

    • Author(s)
      吉見知子,森内絵美,藤下あゆみ,中村 文,内海 大,吉見圭子,古賀義之,蔡 吉陽,吉田教明
    • Organizer
      第54回日本顎口腔機能学会学術大会
    • Place of Presentation
      鹿児島県鹿児島市鹿児島大学郡元キャンパス学習交流プラザ
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 高精度ハイスピードカメラと動物実験用3DマイクロX線を用いたマウス下顎運動包括的解析システムの構築2014

    • Author(s)
      内海 大,濱中 僚, 森内絵美,吉見知子,藤下あゆみ,中村 文,古賀義之,吉田教明
    • Organizer
      第73回日本矯正歯科学会大会
    • Place of Presentation
      千葉県千葉市幕張メッセ
    • Year and Date
      2014-10-20 – 2014-10-22
    • Related Report
      2014 Research-status Report
  • [Remarks] 長崎大学研究者総覧

    • URL

      http://research.jimu.nagasaki-u.ac.jp/IST?ISTActId=FINDJPDetail&userId=100000689

    • Related Report
      2014 Research-status Report
  • [Remarks] 長崎大学教員個人業績

    • URL

      http://gyoseki.jimu.nagasaki-u.ac.jp/IST?ISTActId=RESULTSJPDetail&ISTKidoKbn=&ISTErrorChkKbn=&ISTFormSetKbn=&ISTTokenChkKbn=&userId=100000689

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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