| Project/Area Number |
26861796
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨粗鬆症 |
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| Outline of Final Research Achievements |
This study was conducted to clarify how the drug for treatment of osteoporosis affects orthodontic tooth movement, root resorption, and alveolar bone in orthodontic patients.
Ten-week-old female Wistar rats were divided into three groups: Control, ovariectomy (OVX), and OVX with ZOL administration (OVX + ZOL) group. Their alveolar bone changes were measured by micro-CT images. Bone mineral density (BMD) and bone mineral content to tissue volume ratio (BMC/TV) were significantly decreased in the OVX group compared to the Control group. Bone mineral content (BMC), bone volume (BV), and tissue volume (TV) were significantly increased in the OVX + ZOL group compared to the Control and OVX groups. Meanwhile 10-week-old female Sprague-Dawley rat were divided into Control and lithium chloride administration groups. Tooth movement and root resorption were significantly decreased by lithium chloride administration.
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