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Pharmacological evaluation of the animal model of orthodontic treatment-induced pain.

Research Project

Project/Area Number 26861799
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionMeikai University

Principal Investigator

SASAKI Au  明海大学, 歯学部, 助教 (60580230)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords電気生理刺激 / 矯正装置 / ラット / 開咬反射 / 電気生理 / 矯正治療 / 開口反射
Outline of Final Research Achievements

In the present study, the animal model for quantitative evaluation of the experimental orthodontic force-induced pain was established. The experimental orthodontic force was applied between maxillary incisors and right maxillary first molar by coil-spring. At one (D1), three (D3) and seven (D7) days after orthodontic force application, passing current was applied to bilateral maxillary first molar gingiva to evoke jaw-opening reflex then threshold for inducing jaw-opening reflex was compared between left and right side stimulations. At D1, significant reduction of the threshold for inducing jaw-opening reflex in right (orthodontic) side compared with that of left (control) side was observed. The significant reduction of right side threshold was disappeared at D3 and it was exceeded the left side threshold at D7. These results were presented at several congress meetings (e.g., Neuroscience 2013, 2014 & 2015,74 th Japan Orthodontic Society: Poster Award).

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2015 2014

All Presentation (4 results)

  • [Presentation] Temporal alterations of morphological and physiological features in experimental tooth movement model rats2015

    • Author(s)
      Naoya Hasegawa, Au Sasaki, Kenjiroh Takahashi, Gaden Yu, Naoto Suda, Hiroshi Sakagami and Kazunori Adachi
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      Chicago, America
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Morphological and physiological alterations evoked by orthodontic force in rats2014

    • Author(s)
      A. Sasaki, N. Hasegawa, K. Takahashi, G. Yun, T. Nagao, N. Suda, H. Sakagami and K. Adachi
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington convention center, Washington DC
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 矯正治療に伴う疼痛に対する動物モデルを用いた評価系の開発 -第2報 歯の移動距離と発痛のタイミング-2014

    • Author(s)
      長谷川 尚哉, 佐々木 会, 坂上 宏, 天野 修, 安達 一典, 須田 直人
    • Organizer
      第73回 日本矯正歯科学会大会
    • Place of Presentation
      幕張メッセ、千葉県、幕張市
    • Year and Date
      2014-10-20 – 2014-10-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 矯正治療に伴う疼痛に対する動物モデルの薬理学的評価2014

    • Author(s)
      佐々木 会, 長谷川 尚哉, 坂上 宏, 天野 修, 安達 一典, 須田 直人
    • Organizer
      第56回 歯科基礎医学会
    • Place of Presentation
      福岡国際会議場、福岡県、博多
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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