Feeding-stimulating factor modulates synaptic transmission in the insular cortex
| Project/Area Number |
26861801
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
TAKEI Hiroki 日本大学, 歯学部, 助教 (50632543)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | オレキシン / 島皮質 / 局所神経回路 / パッチクランプ / オレキシンＡ / オレキシンンＢ / 抑制性シナプス後電流 |
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| Outline of Final Research Achievements |
Orexin and MCH are hormone that increase appetite. The insular cortex (IC) expresses these receptors. However almost no information is about the functional roles of these hormones in the IC. To explore this, I performed multiple whole-cell patch clamp recording in the rat IC slice preparation.Orexin A increased the amplitude of unitary inhibitory postsynaptic current (uIPSC) in fast-spiking neuron (FS) to pyramidal cell (Pyr) connections. Same as orexin A, I found that the amplitude of uIPSC in FS to Pyr was increased by orexin B. Pre-application of SB334867 that orexin receptor 1 antagonist diminished the orexin A/B-induced facilitation of uIPSC.
These result suggest orexin is likly to play a role in suppression of gustatory information processing in the IC.
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Report
(4 results)
Research Products
(1 results)
