Masticatory muscle plasticity in mouse
| Project/Area Number |
26861803
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthodontics/Pediatric dentistry
|
|---|
| Research Institution | Tsurumi University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
|---|
| Keywords | 咀嚼筋 / シグナル伝達 / デキサメタゾン / 筋萎縮 / 筋線維タイプ / 筋肥大 / マイクロRNA |
|---|
| Outline of Final Research Achievements |
Masticatory muscles have the potential to adapt their mass and fiber types to a wide range of functional demands, as observed in limb muscles. However, these molecular mechanisms are poorly understood. In this study, we analyzed the effects of bite-opening treatment (BO) on muscle phenotypes of mice masseter muscle. To examine hypertrophic effects of BO on masseter and soleus muscles as well as antagonistic action of dexamethasone (DEX), a glucocorticoid, against hypertrophy, we analyzed both muscle mass and fiber diameter of masseter, soleus muscles in BO and/or DEX-treated mice. These results suggest that differences in the sensitivity to DEX or in the mechanisms of DEX antagonism between masseter and soleus muscles.
|
Report
(4 results)
Research Products
(3 results)
