| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
At first, I clarified that the liposome for targeting inflammatory tissue accumulated at inflammatory periodontal tissue in mouse model of experimental periodontitis. Then, I examined connotation of TGF-β-related protein to the liposome and focused on HMGB1 neutralizing antibody which acted on GDF5, belonged to TGF-β superfamily. HMGB1 was reported the participation to various inflammatory diseases. And HMGB1 neutralizing antibody is expected as new therapeutic drug for those diseases.
As the second step of this study, I manufactured the liposome involving HMGB1 neutralizing antibody. And I clarified that the liposome significantly inhibited progression of periodontitis in comparison with the simple substance dosage of HMGB1 neutralizing antibody.
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