Influences of CCL19-CCR7 pathway on obesity-induced metabolic disease

• Project/Area Number: 26861816
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Periodontology
• Research Institution: Kyushu University
• Principal Investigator: Iwashita Misaki 九州大学, 大学病院, 助教 (80611326)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: CCL19 / CCR7 / 脂肪組織 / インスリン抵抗性 / 樹状細胞 / ccl19 / 脂肪細胞 / マクロファージ

Outline of Final Research Achievements

This study aimed to evaluate the role of CCL19-CCR7 axis on obesity and insulin resistance. CCL19 protein was elevated in the sera of obese model mice challenged by endotoxin. Ccr7(-/-) mice were protected from diet-induced obesity, insulin resistance, fatty liver and dyslipidemia and exhibited increased thermogenesis on high-fat feeding. CCL19 attracts activated dendritic cells. The expression of dendritic cell markers, CD11b and CD11c, was not observed in the adipose tissues of Ccr7(-/-) mice fed a high-fat diet, which might be closely associated with the protection of these mice from obesity.
In this study, we demonstrated that CCL19-CCR7 pathway played a crucial role in inducing obesity and subsequent insulin resistance.

Research Products

• [Journal Article] Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling. (2015)
  • Author(s): Sano T, Iwashita M, Nagayasu S, Yamashita A, Shinjo T, Hashikata A, Asano T, Kushiyama A, Ishimaru N, Takahama Y, Nishimura F
  • Journal Title: Obesity Volume: 23 Issue: 7 Pages: 1460-1471
  • DOI: 10.1002/oby.21127
  • Peer Reviewed / Open Access
• [Presentation] CCL19-CCR7経路がエネルギー消費に及ぼす影響に関する検討 (2015)
  • Author(s): 佐野 朋美、岩下 未咲、山下 明子、新城 尊徳、箸方 厚之、永安 慎太郎、西村 英紀
  • Organizer: 第58回日本歯周病学会春季学術大会
  • Place of Presentation: 幕張メッセ国際会議場
  • Year and Date: 2015-05-15
• [Presentation] CCR7経路が肥満およびインスリン抵抗性に及ぼす影響に関する検討 (2014)
  • Author(s): 佐野 朋美、岩下 未咲、山下 明子、永安 慎太郎、新城 尊徳、箸方 厚之、西村 英紀
  • Organizer: 第57回日本歯周病学会春季学術大会
  • Place of Presentation: 長良川国際会議場
  • Year and Date: 2014-05-23 – 2014-05-24
• [Presentation] CCR7経路が肥満およびインスリン抵抗性に及ぼす影響に関する検討 (2014)
  • Author(s): 岩下 未咲、佐野 朋美、新城 尊徳、箸方 厚之、浅野 知一郎、西村英紀
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-05-22 – 2014-05-24