elucidation of the onset mechanism of alveolar bone resorption and attachment loss based on T cells
Project/Area Number |
26861820
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Periodontology
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Research Institution | Nagasaki University |
Principal Investigator |
TAKAMORI Akiko 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (30631478)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 歯周組織破壊 / T細胞 / 免疫複合体 / 歯周炎 / attachment loss / 歯槽骨吸収 |
Outline of Final Research Achievements |
It is widely known that T cells are promotively involved in alveolar bone resorption, but involvement in periodontitis in the presence of immunecomplexes has not been elucidated. In this study, we investigated the involvement of T cells in periodontal pocket formation and alveolar bone resorption by using nude rats deficient in mature T cells with our experimental periodontitis model which we have established. As a result, against expectations, inhibition of bone resorption of nude rats was not occurred. On the contrary, periodontal tissue destruction was significantly progressed in nude rats as compared with wild type rats.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Nakatsu S, Yoshinaga Y, Kuramoto A, Nagano F, Ichimura I, Oshino K, Yoshimura A, Yano Y, Hara Y2014
Author(s)
Nakatsu S, Yoshinaga Y, Kuramoto A, Nagano F, Ichimura I, Oshino K, Yoshimura A, Yano Y, Hara Y
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Journal Title
Journal of Periodontal Research
Volume: 49
Issue: 3
Pages: 314-322
DOI
Related Report
Peer Reviewed
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[Presentation] ラット実験的歯周炎モデルを用いた歯周炎とインプラント周囲炎の病理組織学的比較2015
Author(s)
髙森雄三, 中村弘隆, 藏本明子, 吉村篤利, 鵜飼 孝, 尾崎幸生, 白石千秋, 山下恭德, 泉 聡史, 小林弘樹, 小山美香, 原 宜興
Organizer
第143回日本歯科保存学会2015年度秋季学術大会
Place of Presentation
文京シビックホール(東京都)
Year and Date
2015-11-12
Related Report
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[Presentation] Histopathological Comparison Of Destruction Between Peri-implant And Periodontal Tissue In Rats.2015
Author(s)
Yuzo Takamori, Akiko Takamori, Yasunori Yoshinaga, Takashi Ukai, Yukio Ozaki, Chiaki Shiraishi, Satoshi Izumi, Hiroki Kobayashi, Hirotaka Nakamura, Atsutoshi Yoshimura, Yoshitaka Hara
Organizer
11th APSP meeting
Place of Presentation
Bali, Indonesia
Year and Date
2015-10-08
Related Report
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[Presentation] topical application of glycyrrhetinic acid into rat gingival sulcus inhibits periodontal destruction induced by lipopolisaccharide.2015
Author(s)
Akiko Takamori, Yasunori Yoshinaga, Takashi Ukai, Hirotaka Nakamura, Yuzo Takamori, Yasunori Yamashita, Satoshi Izumi, Hiroki Kobayashi, Chiaki Shiraishi, Yoshitaka Hara
Organizer
IAP Meeting Chile 2015
Place of Presentation
Santiago, Chile
Year and Date
2015-04-17
Related Report
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[Presentation] TLR2およびTLR4リガンド投与マウス歯肉における炎症性および抗炎症性サイトカインの発現2014
Author(s)
尾崎幸生, 吉村篤利, 金子高士, 鵜飼孝, 吉永泰周, Jorge Montenegro, Ziauddin SM, 白石千秋, 中村弘隆, 藏本明子, 原宜興
Organizer
日本歯科保存学会2014年度秋季学術大会
Place of Presentation
山形テルサ(山形県山形市)
Year and Date
2014-10-30 – 2014-10-31
Related Report
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