| Project/Area Number |
26861820
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Nagasaki University |
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Principal Investigator |
TAKAMORI Akiko 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (30631478)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯周組織破壊 / T細胞 / 免疫複合体 / 歯周炎 / attachment loss / 歯槽骨吸収 |
|---|
| Outline of Final Research Achievements |
It is widely known that T cells are promotively involved in alveolar bone resorption, but involvement in periodontitis in the presence of immunecomplexes has not been elucidated. In this study, we investigated the involvement of T cells in periodontal pocket formation and alveolar bone resorption by using nude rats deficient in mature T cells with our experimental periodontitis model which we have established. As a result, against expectations, inhibition of bone resorption of nude rats was not occurred. On the contrary, periodontal tissue destruction was significantly progressed in nude rats as compared with wild type rats.
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