The association between atherosclerosis and Aa that is a periodontal pathogenic bacteria.

Research Project

Project/Area Number	26861821
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Periodontology
Research Institution	Kagoshima University
Principal Investigator	Shimotahira Naohiro 鹿児島大学, 医歯学域歯学系, 助教 (20710007)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	Aa / Omp100 / アテローム性動脈硬化症 / 歯周病原性細菌
Outline of Final Research Achievements	Periodontal disease has been pointed out relevance to atherosclerosis. The purpose of this study is to analyze the reaction of periodontal pathogenic bacteria Aggregatibactor actinomycetemcomitans and vascular endothelial cells. We found that was increased expression of inflammatory cytokines and adhesion factor of vascular endothelial cells by the supernatant after fracturing A. actinomycetemcomitans. We also found that was promoted adhesion of vascular endothelial cells and monocytes by supernatant after fracturing A. actinomycetemcomitans. Therefore, we suggested that A. actinomycetemcomitans was involved in the pathogenesis of atherosclerosis.