Investigating the effect of serum antibodies to periodontal bacteria on cardiorenal association

• Project/Area Number: 26861827
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: Iwasaki Masanori 九州歯科大学, 歯学部, 准教授 (80584614)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 歯周病 / 慢性腎臓病 / 心血管疾患 / 疫学 / 心腎連関

Outline of Final Research Achievements

Recent epidemiological study confirmed cardiorenal association. Periodontal disease is thought to play important role in cardiovascular and renal function. However, its effect on cardiorenal association has not been fully studied yet.
We investigated the effect of serum antibodies to periodontal bacteria on cardiorenal association.
Based on the results of epidemiological survey of community-based population and hemodialysis patient group, we confirmed that periodontal disease was significantly associated with renal and cardiovascular status. Future studies evaluating the potential effect of oral interventions for periodontal health improvement on cardiorenal function in these study population would be of great interest.

Research Products

• [Journal Article] Periodontitis and health-related quality of life in hemodialysis patients (2017)
  • Author(s): Iwasaki M, Borgnakke WS, Awano S, Yoshida A, Hamasaki T, Teratani G, Kataoka S, Kakuta S, Soh I, Ansai T, Nakamura H.
  • Journal Title: Clinical and Experimental Dental Research Volume: 3(1) Issue: 1 Pages: 13-18
  • DOI: 10.1002/cre2.50
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The association between dentition status and sarcopenia in Japanese adults aged >75 years (2017)
  • Author(s): Iwasaki M, Kimura Y, Ogawa H, Wada T, Sakamoto R, Ishimoto Y, Fujisawa M, Okumiya K, Ansai T, Miyazaki H, Matsubayashi K.
  • Journal Title: Journal of Oral Rehabilitation Volume: 44(1) Pages: 51-58
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Maximum bite force at age 70 years predicts all-cause mortality during the following 13 years in Japanese men (2016)
  • Author(s): Iwasaki M, Yoshihara A, Sato N, Sato M, Taylor GW, Ansai T, Ono T, Miyazaki H.
  • Journal Title: Journal of Oral Rehabilitation Volume: 43(8) Issue: 8 Pages: 565-574
  • DOI: 10.1111/joor.12401
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Longitudinal association of dentition status with dietary intake in Japanese adults aged 75 to 80 years (2016)
  • Author(s): Iwasaki M, Yoshihara A, Ogawa H, Sato M, Muramatsu K, Watanabe R, Ansai T, Miyazaki H
  • Journal Title: Journal of Oral Rehabilitation Volume: 43(10) Issue: 10 Pages: 737-744
  • DOI: 10.1111/joor.12427
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between tooth loss and medical costs related to stroke in healthy elderly aged over 75 years in Japan (2016)
  • Author(s): Iwasaki M, Sato M, Yoshihara A, Ansai T, Miyazaki H
  • Journal Title: Geriatrics & Gerontology International Volume: N/A Issue: 2 Pages: 202-210
  • DOI: 10.1111/ggi.12687
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Longitudinal relationship of severe periodontitis with cognitive decline in older Japanese (2016)
  • Author(s): Iwasaki M, Yoshihara A, Kimura Y, Wada T, Sakamoto R, Ishimoto Y, Fukutomi E, Chen W, Imai H, Fujisawa M, Okumiya K, Taylor GW, Ansai T, Miyazaki H, Matsubayashi K
  • Journal Title: Journal of Periodontal Research Volume: N/A Issue: 5 Pages: 681-8
  • DOI: 10.1111/jre.12348
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Oral health status in relation to cognitive function among older Japanese (2015)
  • Author(s): Iwasaki M, Kimura Y, Yoshihara A, Ogawa H, Yamaga T, Sato M, Wada T, Sakamoto R, Ishimoto Y, Fukutomi E, Chen W, Imai H, Fujisawa M, Okumiya K, Taylor GW, Ansai T, Miyazaki H, Matsubayashi K
  • Journal Title: Clinical and Experimental Dental Research Volume: 1 Issue: 1 Pages: 3-9
  • DOI: 10.1002/cre2.2
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Low dietary diversity among older Japanese adults with impaired dentition. (2015)
  • Author(s): Iwasaki M, Kimura Y, Yoshihara A, Ogawa H, Yamaga T, Wada T, Sakamoto R, Ishimoto Y, Fukutomi E, Chen W, Imai H, Fujisawa M, Okumiya K, Manz MC, Ansai T, Miyazaki H, Matsubayashi K
  • Journal Title: Journal of Dentistry and Oral Hygiene Volume: 7(4) Issue: 5 Pages: 71-77
  • DOI: 10.5897/jdoh2015.0147
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cystatin C-based estimated glomerular filtration rate and periodontitis (2015)
  • Author(s): Iwasaki M, Taylor GW, Sato M, Nakamura K, Yoshihara A, Miyazaki H.
  • Journal Title: Gerodontology Volume: N/A Issue: 3 Pages: 328-334
  • DOI: 10.1111/ger.12159
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Longitudinal relationship between metabolic syndrome and periodontal disease among Japanese adults aged ≥70 years: the Niigata Study (2015)
  • Author(s): Iwasaki M, Sato M, Minagawa K, Manz MC, Yoshihara A, Miyazaki H.
  • Journal Title: Journal of Periodontology Volume: N/A Issue: 4 Pages: 491-498
  • DOI: 10.1902/jop.2015.140398
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between dental status and food diversity among older Japanese (2015)
  • Author(s): Iwasaki M, Kimura Y, Yoshihara A, Ogawa H, Yamaga T, Takiguchi T, Wada T, Sakamoto R, Ishimoto Y, Fukutomi E, Chen W, Imai H, Fujisawa M, Okumiya K, Manz MC, Miyazaki H, Matsubayashi K.
  • Journal Title: Community Dental Health Volume: N/A
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hyposalivation and dietary nutrient intake among community-based older Japanese (2015)
  • Author(s): Iwasaki M, Yoshihara A, Ito K, Sato M, Minagawa K, Muramatsu K, Watanabe R, Manz MC, Ansai T, Miyazaki H.
  • Journal Title: Geriatrics & Gerontology International Volume: N/A
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Serum antibody to Porphyromonas gingivalis in metabolic syndrome among an older Japanese population (2014)
  • Author(s): Masanori Iwasaki, Kumiko Minagawa, Misuzu Sato, Noboru Kaneko, Susumu Imai, Akihiro Yoshihara and Hideo Miyazaki
  • Journal Title: Gerodontology Volume: 13 Issue: 2 Pages: 1-8
  • DOI: 10.1111/ger.12135
  • Peer Reviewed
• [Presentation] Pneumonia Mortality Is Associated With Periodontitis in Patients Undergoing Hemodialysis (2017)
  • Author(s): Iwasaki M, Taylor GW, Awano S, Yoshida A, Hamasaki T, Teratani G, Soh I, Ansai T, Nakamura H.
  • Organizer: 2017 IADR/AADR/CADR General Session & Exhibition.
  • Place of Presentation: San Fransisco, CA, U.S.
  • Year and Date: 2017-03-22
  • Int'l Joint Research
• [Presentation] 透析患者における歯周病と健康関連Quality of Lifeの関連 (2016)
  • Author(s): 岩崎正則，粟野秀慈，有永靖，片岡正太，角田聡子，邵仁浩，濱嵜朋子，吉田明弘，安細敏弘
  • Organizer: 第65回 日本口腔衛生学会・総会
  • Place of Presentation: 東京都
  • Year and Date: 2016-05-27
• [Presentation] 地域在住高齢者における歯周病が認知機能の変化に与える影響 (2015)
  • Author(s): 岩崎正則，葭原明弘，安細敏弘，宮崎秀夫
  • Organizer: 第26回一般社団法人日本老年歯科医学会
  • Place of Presentation: 横浜市
  • Year and Date: 2015-06-12
• [Presentation] 地域在住高齢者における歯・口腔の健康が認知機能検査スコアに与える影響 (2015)
  • Author(s): 岩崎正則，葭原明弘，小川祐司，山賀孝之，佐藤美寿々，安細敏弘，宮崎秀夫
  • Organizer: 第64回 日本口腔衛生学会・総会
  • Place of Presentation: つくば市
  • Year and Date: 2015-05-27
• [Presentation] Association between oral health status and cognitive function among older Japanese (2015)
  • Author(s): Iwasaki M, Taylor GW, Sato M, Ogawa H, Yoshihara A, Yamaga T, Kimura Y, Wada T, Sakamoto R, Ishimoto Y, Fukutomi E, Chen W, Imai H, Fujisawa M, Okumiya K, Otsuka K, Miyazaki H, Matsubayashi K.
  • Organizer: IADR/AADR/CADR General Session & Exhibition - Boston, Massachusetts
  • Place of Presentation: アメリカ、ボストン
  • Year and Date: 2015-03-11 – 2015-03-14
• [Remarks] 九州歯科大学地域健康開発歯学分野
  • URL: http://www2.kyu-dent.ac.jp/dept/oral-health/
• [Remarks] 九州歯科大学 地域健康開発歯学分野
  • URL: http://www2.kyu-dent.ac.jp/dept/oral-health/
• [Remarks] 新潟大学大学院医歯学総合研究科口腔健康科学講座予防歯科学分野
  • URL: http://www.dent.niigata-u.ac.jp/prevent/japanese/index.html