Relationship between Cnm-positive Streptococcus mutans and cerebral microbleeds in humans

• Project/Area Number: 26861835
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Watanabe Isao 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10636525)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: う蝕原性細菌 / Cnmタンパク / 無症候性脳出血 / 微小脳出血 / 社会系歯学 / う蝕菌 / 認知機能

Outline of Final Research Achievements

We have shown that the surface Cnm protein expressed on cnm-positive Streptococcus mutans is involved in development of CMBs. Two-hundred ninty-seven community residents (70.0 years), were examined for the presence or absence of cnm-positive S. mutans in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated. Cnm-positive Streptococcus mutans was detected more often among subjects with CMB (p < 0.01) than those without. The risk of CMBs was significantly higher (odds ratio=12.3) in the group with than without S. mutans expressing collagen binding activity. Deep CMBs were more frequent (72%) and cognitive function was lower among subjects with cnm-positive S. mutans expressing collagen binding activity. This work supports the role of oral health in stroke and dementia and proposes a molecular mechanism for the interaction.

Research Products

• [Journal Article] Relationship between Cnm-positive Streptococcus mutans and cerebral microbleeds in humans. (2015)
  • Author(s): Miyatani F, Kuriyama N, Watanabe I, Nomura R, Nakano K, Matsui D, Ozaki E, Koyama T, Nishigaki M, Yamamoto T, Mizuno T, Tamura A, Akazawa K, Takada A, Takeda K, Yamada K, Nakagawa M, Ihara M, Kanamura N, Friedland RP, Watanabe Y.
  • Journal Title: Oral Diseases Volume: 21 Issue: 7 Pages: 886-893
  • DOI: 10.1111/odi.12360
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 残存歯数およびアイヒナー分類による咬合支持域と軽度認知機能低下の関連 (2015)
  • Author(s): 渡邉 功, 宮谷 史太郎, 岩井 浩明, 松井 大輔, 加藤 里佳, 大道 智恵, 田中 里佳, 橋口 加名栄, 小山 晃英, 尾崎 悦子, 栗山 長門, 渡邊 能行
  • Organizer: 第７４回日本公衆衛生学会総会
  • Place of Presentation: 長崎ブリックホール
  • Year and Date: 2015-11-04
• [Presentation] Cmn-positive S.mutans感染と、脳内微小出血を有する認知機能低下が関連する (2015)
  • Author(s): 栗山 長門, 渡邉 功, 宮谷 史太郎, 松井 大輔, 尾崎 悦子, 仲野 和彦, 武田 和夫, 中川 正法, 水野 敏樹, 渡邊 能行
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール青森
  • Year and Date: 2015-10-02
• [Presentation] ヒトにおける齲蝕原性細菌(Streptococcus mutans)及び口腔内状態と脳内微小出血の関連の検討 (2014)
  • Author(s): 山本 俊郎、宮谷 史太郎、渡邉 功、 et al.
  • Organizer: 第27回京都府歯科医学大会
  • Place of Presentation: きらっ都プラザ京都産業会館
  • Year and Date: 2014-09-28