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Elucidation of pathological condition of oral cavity management and chronic oral GVHD in hematopoietic stem cell transplantation

Research Project

Project/Area Number 26861848
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Social dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

SAKUMA Hidenori  愛知学院大学, 歯学部, 非常勤講師 (60453065)

Research Collaborator NAGAO Toru  愛知学院大学, 歯学部, 教授 (90261007)
OH-IWA Ichiro  愛知学院大学, 歯学部, 非常勤講師 (80421254)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords造血幹細胞移植 / 口腔慢性GVHD / 口腔管理 / 専門的口腔清掃 / 口腔慢性GVHD / HPV / 慢性GVHD
Outline of Final Research Achievements

Professional oral cavity cleaning was selected as a factor to alleviate the severity of oral mucosal damage at the time of hematopoietic stem cell transplantation and the utility of oral care at the time of transplantation was proved. The oral mucosa of patients with oral chronic GVHD was examined by fluorescence observation method and it was suggested that inflammation may remain if the case evaluated that oral mucosa symptoms were improved by fluorescence observation method. The relationship between NIH OMS and histopathological findings of lip tissue was found, but it was not related to small salivary gland tissue. Immunostaining suggesting HPV infection The study of P16 was positive in oral chronic GVHD lip tissues and small salivary gland tissues, suggesting that there is some association between HPV infection and the pathology of oral chronic GVHD.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2014

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] p53 and ki67 as biomarkers in determining response to chemoprevention for oral leukoplakia2017

    • Author(s)
      Nagao T, Warnakulasuriya S, Sakuma H, et al
    • Journal Title

      J Oral Pathol Med

      Volume: 46 Issue: 5 Pages: 346-352

    • DOI

      10.1111/jop.12498

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 口腔慢性GVHDにおけるNIH Oral Mucosal Scoreの有用性の検討2017

    • Author(s)
      佐久間英規 佐藤春樹 長縄憲亮 他
    • Organizer
      第27回 日本口腔内科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 当院緩和ケアセンターにおける口腔関連有害事象の検討2016

    • Author(s)
      佐久間 英規, 川原 侑子, 小野 翔矢, 他
    • Organizer
      第70回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 当院の造血幹細胞移植におけるオーラルマネージメントの検討2016

    • Author(s)
      佐久間英規 佐藤春樹 野田晴菜 大岩伊知郎 他
    • Organizer
      第38回日本造血幹細胞移植学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 造血幹細胞移植患者の口腔内評価について2014

    • Author(s)
      犬飼桂子 中山桂子 日比野朋美 杉本美来 古橋采奈 清水梨奈 中村阿由美 竹内麻里加 佐久間英規 大岩伊知郎
    • Organizer
      第50回日本赤十字社医学会総会
    • Place of Presentation
      熊本県 市民会館崇城大学ホール
    • Year and Date
      2014-10-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 当科で口唇生検を実施した造血幹細胞移植患者の検討2014

    • Author(s)
      佐久間英規 佐藤春樹 高木雄基 大岩伊知郎
    • Organizer
      第24回日本口腔内科学会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-09-20
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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