Establishment of dietary therapy for dermatological disorder of obesity - Evaluation of efficacy of gallic acid -

• Project/Area Number: 26861860
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Fundamental nursing
• Research Institution: Yokohama City University
• Principal Investigator: Makihara Hiroko 横浜市立大学, 医学研究科, 嘱託員 (00708696)
• Research Collaborator: AKASE Tomoko
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 肥満 / 皮膚障害 / 食事療法 / Gallic acid / 脂肪細胞 / 皮膚

Outline of Final Research Achievements

Recently, it has been reported that skin disorders tend to develop in obesity,but research on its pathophysiological mechanism and prevention is very few. The skin plays an important role as immune system, and declining QOL due to skin disorders is remarkable. So it is strongly desired to prevent the onset of skin disorders by taking care of it as soon as possible.
In this study, we investigated the preventive effect of Gallic acid (GA), the natural component having antioxidant effect, on obesity skin disorder. It was showed that GA inhibited hypertrophy of adipocytes in subcutaneous tissues on obese model mice.　Furthermore and it is clear that analysis using cultured cells promotes adipocyte differentiation and promotes secretion of good cytokine adiponectin became.

Research Products

• [Journal Article] Gallic Acid, the Active Ingredient of <i>Terminalia bellirica</i>, Enhances Adipocyte Differentiation and Adiponectin Secretion (2016)
  • Author(s): Makihara H, Koike Y, Ohta M, Horiguchi-Babamoto E, Tsubata M, Kinoshita K, Akase T, Goshima Y, Aburada M, Shimada T.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 7 Pages: 1137-1143
  • DOI: 10.1248/bpb.b16-00064
  • NAID: 130005160767
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Acknowledgement Compliant