| Project/Area Number |
26861872
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fundamental nursing
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Research Collaborator |
SAKAI AZUKI 山形大学, 大学院医学系研究科看護学専攻
KANNO Sumika 山形大学, 大学院医学系研究科看護学専攻
Goto Nozomi 山形大学, 大学院医学系研究科看護学専攻
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 排尿機能 / 加齢変化 / F344rat / serotonin / セロトニン / 日内変動 / 排尿リズム |
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| Outline of Final Research Achievements |
The question has remained unanswered how the nocturia increases by getting old. Although, there are many influencing factors, some recent studies have suggested that the change of the biological clock causes the nocturia . Therefore the present study was undertaken in order to investigate whether the bladder body contraction by serotonin (5-HT) has influenced with aging in experimental animal. 5-HT is a precursor of the melatonin that is maintaining the biological clock, and it has been reported that the 5-HT-induced contraction has increased in the overactive bladder. Our results suggested that the 5-HT-induced contraction has changed in aged bladder, moreover the mechanism can change.
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