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The establishing a novel technical measure of nutritional status using the wound fluid

Research Project

Project/Area Number 26861876
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Fundamental nursing
Research InstitutionTokyo University of Agriculture

Principal Investigator

Yamane Takumi  東京農業大学, 応用生物科学部, 助教 (80637314)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords浸出液 / 創傷治癒 / 栄養 / FGF21 / IGF-1 / IGFBP-1 / IL-1β / IL-10 / タンパク質栄養 / 滲出液 / 皮膚
Outline of Final Research Achievements

It is necessary to establish a brief and simplified method for evaluation of nutritional status during the wound healing process because malnutrition is closely associated with protracted wound healing. In the present study, we used an animal model to examine effects of protein free (PF) or gluten diets on wound fluid component changes in rats. Wound exudate and serum samples were collected to analyze. The concentrations of insulin like growth factor (IGF)-1, IGF-binding protein-1, and fibroblast growth factor 21 in the wound fluid and serum obtained from rats fed a PF diet markedly changed. The concentrations of interleukin (IL)-1β and IL-10 in the wound fluid obtained from rats fed a gluten diet markedly changed. These results show that these molecules in the wound fluid are available as a nutritional biomarker. This study would contribute to the establishing a novel technical measure of nutritional status during the wound healing process.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) Remarks (3 results)

  • [Journal Article] Effects of an amino acid deficiency on hyaluronan synthesis in human dermal fibroblasts2016

    • Author(s)
      Takumi Yamane, Yoshiki Inoue, Kazuo Kobayashi-Hattori, Yuichi Oishi
    • Journal Title

      Food Science and Technology Research

      Volume: 22 Pages: 279-281

    • NAID

      130005147057

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 食餌中のタンパク質の質の違いが創傷治癒に及ぼす影響2016

    • Author(s)
      上岡美沙,山根拓実,岩槻健,大石祐一
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分岐鎖アミノ酸(BCAA)が皮膚機能に及ぼす影響2016

    • Author(s)
      森岡由夏,岩槻健,大石祐一,北浦靖之,下村吉治,山根拓実
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質栄養の悪化による滲出液の成分変化が創傷治癒に与える影響2016

    • Author(s)
      志村茉里,岩槻健,大石祐一,山根拓実
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] FGF21が皮膚機能に及ぼす影響2015

    • Author(s)
      志村茉里,山根拓実,岩槻健,竹中麻子,大石祐一
    • Organizer
      日本アミノ酸学会第9回学術大会
    • Place of Presentation
      滋賀県立大学
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質栄養低下が創傷治癒関連遺伝子に及ぼす影響2015

    • Author(s)
      志村茉里,山根拓実,岩槻健,大石祐一
    • Organizer
      日本食生活学会第50回記念大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質栄養低下による創傷治癒遅延の分子メカニズムの解明2014

    • Author(s)
      志村茉里,山根拓実,青木遼平,八重樫由佳,岩槻健,大石祐一
    • Organizer
      第44回日本創傷治癒学会
    • Place of Presentation
      ホテルメトロポリタン仙台
    • Year and Date
      2014-12-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Hydrocellular foam dressing貼付による滲出液の成分変化が創傷治癒促進に与える影響2014

    • Author(s)
      吉野佐和子,山根拓実,大平朋美,川崎瑠衣,志村彩夏,向山朱莉,岩槻健,仲上豪二朗,真田弘美,服部一夫,大石祐一
    • Organizer
      第44回日本創傷治癒学会
    • Place of Presentation
      ホテルメトロポリタン仙台
    • Year and Date
      2014-12-02
    • Related Report
      2014 Research-status Report
  • [Remarks] 東京農業大学 教員・研究情報詳細

    • URL

      http://dbs.nodai.ac.jp/html/100000791_ja.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 教員・研究情報詳細

    • URL

      http://dbs.nodai.ac.jp/html/100000791_ja.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 国内発表

    • URL

      http://www.rounenkango.m.u-tokyo.ac.jp/presentation.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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