| Project/Area Number |
26861876
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fundamental nursing
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
Yamane Takumi 東京農業大学, 応用生物科学部, 助教 (80637314)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 浸出液 / 創傷治癒 / 栄養 / FGF21 / IGF-1 / IGFBP-1 / IL-1β / IL-10 / タンパク質栄養 / 滲出液 / 皮膚 |
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| Outline of Final Research Achievements |
It is necessary to establish a brief and simplified method for evaluation of nutritional status during the wound healing process because malnutrition is closely associated with protracted wound healing. In the present study, we used an animal model to examine effects of protein free (PF) or gluten diets on wound fluid component changes in rats. Wound exudate and serum samples were collected to analyze. The concentrations of insulin like growth factor (IGF)-1, IGF-binding protein-1, and fibroblast growth factor 21 in the wound fluid and serum obtained from rats fed a PF diet markedly changed. The concentrations of interleukin (IL)-1β and IL-10 in the wound fluid obtained from rats fed a gluten diet markedly changed. These results show that these molecules in the wound fluid are available as a nutritional biomarker. This study would contribute to the establishing a novel technical measure of nutritional status during the wound healing process.
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